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UNREMITTING EARLY STAGE OF HODGKIN DISEASE: REPORT OF 7 CASES AND BONE MARROW TISSUE IMMUNOHISTOCHEMICAL MARKER STUDY

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Author(s): D. Tamiolakis | S. Nikolaidou | A. Kotini | T. Jivannakis | A. Efthimiadou | P. Boglou | S. Bolioti | J. Venizelos

Journal: jurnalul de chirurgie (journal of surgery)
ISSN 1584-9341

Volume: 3;
Issue: 3;
Start page: 260;
Date: 2007;
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Keywords: HODGKIN’S DISEASE | IMMUNOHISTOCHEMISTRY | BONE MARROW

ABSTRACT
Bone marrow is infrequently implicated in early stage Hodgkin’s disease. We studied the immunohistochemical bone marrow tissue of 7 out of 20 cases with early stage Hodgkin’s disease of the mixed cellularity variant, diagnosed by lymph node biopsy at initial presentation, not responding to radiotherapy alone, in order to examine possible marrow attack. A statistically significant prevalence of CD45, CD45RO, and CD4 positive infiltrates, to the advantage of unremitting hosts, was found. The predominance of CD4 positive cells in the bone marrow space: 1) might be suggestive of involvement in the process; 2) could explain the abnormal cytokine production leading to reduced T-cell immunity and inefficient antitumor response despite the existence of a vast majority of reactive infiltrating immune cells.
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