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Unusual hematologic disease affecting Caucasian children traveling to Southeast Asia: acquired platelet dysfunction with eosinophilia

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Author(s): Anselm Chi-Wai Lee

Journal: Hematology Reports
ISSN 2038-8322

Volume: 4;
Issue: 1;
Start page: e5;
Date: 2012;
Original page

Keywords: acquired platelet dysfunction | eosinophilia | hemorrhage | thrombocytopathy

ABSTRACT
An 11-year-old American boy was staying with his family in Indonesia. He presented with a 5-month history of recurrent bruises and ecchymosis. A clinical diagnosis of acquired platelet dysfunction with eosinophilia was made when his full blood counts showed hypereosinophilia (7.4×10 9/L) with normal platelet count and gray platelets under the microscope. The diagnosis was supported by abnormal platelet aggregation tests consistent with a storage pool disorder. The bleeding symptoms and eosinophilia resolved a month later with a full course of antihelminthic therapy. Hematologists should be aware of this unusual disease in travelers returning from the Southeast Asia.
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