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An unusual T-cell childhood acute lymphoblastic leukemia harboring a yet unreported near-tetraploid karyotype

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Author(s): Garcia Daniela | Bhatt Samarth | Manvelyan Marina | de Souza Mariana | Binato Renata | Aguiar Thais | Abdelhay Eliana | Silva Maria Luiza

Journal: Molecular Cytogenetics
ISSN 1755-8166

Volume: 4;
Issue: 1;
Start page: 20;
Date: 2011;
Original page

Keywords: T-ALL | childhood | near-tetraploidy

ABSTRACT
Abstract Background Near-tetraploid (model #81-103) and near-triploid (model #67-81) karyotypes are found in around 1% of childhood acute lymphoblastic leukemia. Due to its rarity, these two cytogenetic subgroups are generally included in the hyperdiploid group (model # > 51). Therefore separate informations about these two subgroups are limited to a few reports. Some studies found that near-tetraploidy is relatively more frequent in higher median ages and it is associated to Frech-American-British Classification subtype L2. Although the mechanisms by which leukemic blast cells divide is still unclear, studies have suggested that hyperdiploidy, near-triploidy and near-tetraploidy do not seem to share the same mechanism. Findings Herewith, we present a new childhood T-acute lymphoblastic leukemia case of near-tetraploid karyotype with loss of two p53-gene copies, characterized in detail by cytogenetic and molecular studies. Conclusion We suggest that p53 is a good target gene to be screened, once p53 is one of the main effectors of cell cycle checkpoints.
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