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The use of amniotic membrane in trabeculectomy for the treatment of primary open-angle glaucoma: a prospective study

Author(s): Stavrakas P | Georgopoulos G | Milia M | Papaconstantinou D | Bafa M | Stavrakas E | Moschos M

Journal: Clinical Ophthalmology
ISSN 1177-5467

Volume: 2012;
Issue: default;
Start page: 205;
Date: 2012;
Original page

Panagiotis Stavrakas1, Gerasimos Georgopoulos1, Maria Milia1, Dimitris Papaconstantinou1, Maria Bafa2, Efthymios Stavrakas2, Mihalis Moschos11Department of Ophthalmology, University of Athens Medical School, General Hospital of Athens (Geniko Kratiko Hospital), Athens, Greece; 2Department of Ophthalmology, Thriassio General Hospital, Athens, GreeceBackground: To investigate the effectiveness of amniotic membrane transplantation (AMT) on improving the outcomes of trabeculectomy in primary open-angle glaucoma (POAG).Methods: Fifty-nine eyes affected by primary open-angle glaucoma were enrolled in this prospective randomized study. Thirty-two eyes underwent amnion-shielded trabeculectomy (study group) and 27 eyes underwent trabeculectomy without any antimetabolites (control group). Success was defined as intraocular pressure (IOP) 21 mmHg in contrast to seven patients from the classic trabeculectomy group. The study group had 61.0% less risk of developing IOP >21 mmHg (P = 0.203). No major complications in the AMT group were observed. AMT blebs were diffuse with mild vascularization.Conclusion: In patients with POAG, AMT showed favorable effects on bleb survival, however data failed to provide firm evidence that AMT could be used as a routine procedure in trabeculectomy.Keywords: amniotic membrane, trabeculectomy, primary open-angle glaucoma, glaucoma filtering blebIn memory of Professor Mihalis Moschos. "We thank him for his encouragement as well as his leadership and commitment to public health."

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