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USE OF C- REACTIVE PROTEIN IN PLEURAL FLUID FOR DIFFERENTIAL DIAGNOSIS OF BENIGN AND MALIGNANT EFFUSION

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Author(s): Tatjana Radjenovic Petkovic | Tatjana Pejcic | Vojin Savic | Predrag Vlahovic | Desa Nastasijević Borovac | Danijela Radojkovic

Journal: Acta Facultatis Medicae Naissensis
ISSN 0351-6083

Volume: 24;
Issue: 2;
Start page: 89;
Date: 2007;
Original page

Keywords: pleural effusion | C-reactive protein | malignant | nonmalignanat

ABSTRACT
The aim of this study was to determine the validity of pleural fluid Creactiveprotein (CRP) concentrations and pleural fluid /serum CRP ratio fordifferentiating pleural effusion of malignant non-malignant etiology.Pleural fluid and serum CRP levels were obtained in 82 patients withpleural effusion, using an immunoturbidimetric method (Olympus autoanalyser). Patients were subdivided in two groups, group I (n= 41) with malignant,and group II (n=41) with non-malignant (tuberculous, inflammatory, transudative) pleural effusion.Statistical analysis was conducted using the MannWhitney Rank sumtest.There were statistically significant differences in pleural fluid CRPvalues between group I (15.6 ±10.55), and group II (25.7 ±12.475), and therewere significant differences betweenCRPpleural fluid/serum ratio in group I vs.group II (0.318 ±0.157, vs. 0.430± 0.229). In addition, there were statisticallysignificant differences between pleural fluid CRP values in patients withparapneumonic compared to patients with tuberculous and malignant effusions.In differential diagnosis of pleural effusion, pleural fluid CRPmay proverapid and practical method of differentiating malignant from non-malignantpleural effusion.
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