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Use of collagen as an implantable material in the reconstructive procedures - an overview

Author(s): R. Khan

Journal: Biology and Medicine
ISSN 0974-8369

Volume: 3;
Issue: 4;
Start page: 25;
Date: 2011;
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Keywords: Collagen | membranes | guided tissue regeneration

Collagen is an important biomaterial in medical applications due to its special characteristics, such as biodegradabilityand weak antigenicity. Thus collagen, as a new type of biomaterial, has been used in drug delivery systems andtissue engineering. Collagen is capable of being prepared into cross-linked compacted solids or into lattice-like gels.Resorbable forms of collagen have been used to dress oral wounds, for closure of graft and extraction sites, and topromote healing. Collagen-based membranes also have been used in periodontal and implant therapy as barriers toprevent epithelial migration and allow cells with regenerative capacity to repopulate the defect area. It has beenhypothesized that membrane regenerative techniques facilitate the natural biological potential by creating a favorableenvironment for periodontal and peri-implant regeneration. Due to the enormous potential of collagen-basedregenerative barriers, clinicians may benefit from a review of potential applications of implantable collagen andknowledge of collagen preparation and membrane types as well as from as awareness of the functional anddegradation properties of those materials.

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