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Use of rosuvastatin as a geroprotector in people engaged in natural gas producing

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Author(s): A.T. Abdrashitova | T.N. Panova | I.A. Belolapenko | M.V. Frenkel

Journal: Racionalʹnaâ Farmakoterapiâ v Kardiologii
ISSN 1819-6446

Volume: 7;
Issue: 4;
Start page: 447;
Date: 2011;
Original page

Keywords: rosuvastatin | premature aging | gas producing | geroprevention.

ABSTRACT
Aim. To study the geroprotective properties of rosuvastatin in respect of people engaged in the gas producing.Material and methods. The male workers (n=100) of the company “Gazprom dobycha Astrakhan” were examined. Evaluation of biological age by the method of Chebotarev D.F., determination of p53 protein and interleukin-8, 10, 18 concentrations by solid phase enzyme immunoassay were performed before treatment start and after 18 months of rosuvastatin taking.Results. Rosuvastatin therapy in dose of 5 mg/day resulted in the reduction in atherogenic lipids, pro-inflammatory cytokine - interleukin-8 and marker of apoptosis - protein p53 as well as aging rate slowdown.Conclusion. Pathogenic method of geroprevention with rosuvastatin 5 mg/day was proposed for people engaged in gas producing.
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