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The Utility of ANTI-HCV S/CO Ratio, HCV-RNA and ALT Test in Predicting Viremia in ANTI-HCV Positive Patients

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Author(s): Mevhibe Balk | Gülsevim Saydam | Doğan Cengiz | Aygül Türkmen | Hüseyin Şimşek | Tuğrul Himmetoğlu

Journal: Türk Biyokimya Dergisi
ISSN 0250-4685

Volume: 32;
Issue: 2;
Start page: 51;
Date: 2007;
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Keywords: Anti- HCV | HCV-RNA | ALT | Hepatitis C virus infection

ABSTRACT
Hepatitis C Virus (HCV) infection is frequently diagnosed by detection of antibodyagainst the HCV (Anti-HCV). The seropositivity of anti-HCV could reflect chronicinfectious status and/or previous infection. Detection of HCV-RNA by PCR is stilllaborious, too expensive, requires specific expertise and facilities, and usually used toconfirm positive serology. This study was performed in anti-HCV positive patients todetermine the relationship between anti-HCV Sample rate / Cutoff rate (S/CO) ratios,HCV-RNA and Alanine aminotransferase (ALT) levels. In addition, the utility of anti-HCV S/CO ratio values in predicting HCV viremia in anti-HCV positive patients wereevaluated. Serum samples of 124 patients were tested for anti-HCV by a MEIA technique,for HCV-RNA by a quantitative PCR and for ALT by IFCC UV test. S/CO values foranti-HCV test and ALT levels were correlated with the quantitative values of HCV-RNA(respectively, r=0.824, p
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