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Utility of co-transplanting mesenchymal stem cells in islet transplantation

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Author(s): Naoaki Sakata | Masafumi Goto | Gumpei Yoshimatsu | Shinichi Egawa | Michiaki Unno

Journal: World Journal of Gastroenterology
ISSN 1007-9327

Volume: 17;
Issue: 47;
Start page: 5150;
Date: 2011;
Original page

Keywords: Mesenchymal stem cell | Islet transplantation | Bone marrow | Immunomodulatory | Regulatory T cell | Angiogenesis | Vascular endothelial growth factor | Diabetes mellitus

ABSTRACT
Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. The mechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.
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Tango Jona
Tangokurs Rapperswil-Jona