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Validated Spectrophotometric Quantification of Aripiprazole in Pharmaceutical Formulations by Using Multivariate Technique

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Author(s): Kandikonda Sandeep | Madhusudhanareddy Induri | Muvvala Sudhakar

Journal: Advanced Pharmaceutical Bulletin
ISSN 2228-5881

Volume: 3;
Issue: 2;
Start page: 469;
Date: 2013;
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Keywords: Aripiprazole | Tablets | UV-Spectrophotometry | Multivariate Technique

ABSTRACT
Purpose: An accurate and precise UV spectrophotometric method with multivariate calibration technique for the determination of aripiprazole in pharmaceutical formulations has been described. Methods: This technique is based on the use of the linear regression equations by using the relationship between concentration and absorbance at five different wavelengths. The aripiprazole shows absorption maxima at 255 nm and obeyed Beer’s law in the range of 5-30 μg/mL. Results: The results were treated statistically and were found highly accurate, precise and reproducible. This statistical approach gives optimum results for the eliminating fluctuations coming from instrumental or experimental conditions. Conclusion: It was concluded that the proposed method is simple, easy to apply, economical and could be used as an alternative to the existing spectrophotometric and non-spectrophotometric methods for the routine analysis of aripiprazole in pharmaceutical formulations.
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