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Validation of the Japanese version of the Pediatric Quality of Life Inventory (PedsQL) Cancer Module

Author(s): Tsuji Naoko | Kakee Naoko | Ishida Yasushi | Asami Keiko | Tabuchi Ken | Nakadate Hisaya | Iwai Tsuyako | Maeda Miho | Okamura Jun | Kazama Takuro | Terao Yoko | Ohyama Wataru | Yuza Yuki | Kaneko Takashi | Manabe Atsushi | Kobayashi Kyoko | Kamibeppu Kiyoko | Matsushima Eisuke

Journal: Health and Quality of Life Outcomes
ISSN 1477-7525

Volume: 9;
Issue: 1;
Start page: 22;
Date: 2011;
Original page

Abstract Background The PedsQL 3.0 Cancer Module is a widely used instrument to measure pediatric cancer specific health-related quality of life (HRQOL) for children aged 2 to 18 years. We developed the Japanese version of the PedsQL Cancer Module and investigated its reliability and validity among Japanese children and their parents. Methods Participants were 212 children with cancer and 253 of their parents. Reliability was determined by internal consistency using Cronbach's coefficient alpha and test-retest reliability using intra-class correlation coefficient (ICC). Validity was assessed through factor validity, convergent and discriminant validity, concurrent validity, and clinical validity. Factor validity was examined by exploratory factor analysis. Convergent and discriminant validity were examined by multitrait scaling analysis. Concurrent validity was assessed using Spearman's correlation coefficients between the Cancer Module and Generic Core Scales, and the comparison of the scores of child self-reports with those of other self-rating depression scales for children. Clinical validity was assessed by comparing the on- and off- treatment scores using Kruskal-Wallis and Mann-Whitney U tests. Results Cronbach's coefficient alpha was over 0.70 for the total scale and over 0.60 for each subscale by age except for the 'pain and hurt' subscale for children aged 5 to 7 years. For test-retest reliability, the ICC exceeded 0.70 for the total scale for each age. Exploratory factor analysis demonstrated sufficient factorial validity. Multitrait scaling analysis showed high success rates. Strong correlations were found between the reports by children and their parents, and the scores of the Cancer Module and the Generic Core Scales except for 'treatment anxiety' subscales for child reports. The Depression Self-Rating Scale for Children (DSRS-C) scores were significantly correlated with emotional domains and the total score of the cancer module. Children who had been off treatment over 12 months demonstrated significantly higher scores than those on treatment. Conclusions The results demonstrate the reliability and validity of the Japanese version of the PedsQL Cancer Module among Japanese children.
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