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Variable β-globin haplotypes in Saudi β thalassemia population

Author(s): Jameela Shinwari | Tahani Alshehri | Asma I. Tahir | Abdullah Al Jefri | Abdulkareem AlMomen | Dana Bakheet | Mohammad AlAnazi | Arjumand Warsy | Nada Al Tassan

Journal: Open Journal of Genetics
ISSN 2162-4453

Volume: 03;
Issue: 03;
Start page: 171;
Date: 2013;
Original page

Keywords: SNPs | Haplotype | Linkage Disequilibrium | Restriction Sites

Twenty two haplotypes were generated from a pool of 60 unrelated Saudi β thalassemia major patients using previously described restriction sites in the β globin gene. Linkage disequilibrium analysis of the polymorphic sites was also conducted, a few identified haplotypes were novel while the remainder was previously reported, haplotype1222212 was the most frequent haplotype in the study group and a strong linkage disequilibrium between two polymorphic restriction sites in these β thalassemia patients was uncovered.

Tango Jona
Tangokurs Rapperswil-Jona

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