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Vasodilatation Effect of Latex from Calotropis gigantea in Green Frog Rana hexadactyla

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Author(s): B. Sheelaa

Journal: Asian Journal of Medical Sciences
ISSN 2040-8765

Volume: 2;
Issue: 1;
Start page: 22;
Date: 2010;
Original page

ABSTRACT
The latex of Calotropis gigantea is a rich source of useful components that has medicinal propertiesand one of the main applications is in controlling the heart muscle. The crude latex extract contained manyproteins, which are highly basic in nature and exhibited strong dilatation activity. Blood vessel experiment ofthe latex from Calotropis gigantea was studied in the green frog (Rana hexadactyla). The diluted crude extractwith distilled water to 1:10 and 1: 100 concentrations produces percentage increase in the cardiac output.Higher dilution factor increase the cardiac output 1:100 produces 66% output where as 1:10 produces 50%cardiac output. On treating with high dose, the latex damage the contractility of the cardiac muscle. Thus thepresent study reveals that the latex produces vasodilatation effect at fixed dose concentration.
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