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Vazoactive Effects of Oxidative Stress Elicited by Hydrogen Peroxide in the Human Umbilical Artery: An <i>in Vitro</i> Study

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Author(s): Ipek Duman | Necdet Dogan

Journal: Pharmacology & Pharmacy
ISSN 2157-9423

Volume: 02;
Issue: 04;
Start page: 347;
Date: 2011;
Original page

Keywords: Umbilical Arteries | Hydrogen Peroxide | Indomethacin | L-NAME | Oxidative Stress | Pre-Eclampsia | Reactive Oxygen Species | Verapamil

ABSTRACT
The vasoactive effects of oxidative stress induced by hydrogen peroxide (H2O2) on human umbilical artery strips as well as the possible mechanisms involved are studied. Contraction responses to cumulative H2O2 (10–7 M-3 × 10–2 M) in endothelium intact and denuded umbilical arteries and responses to cumulative H2O2 after incubation with L-NAME (10–4 M) (n = 8), indomethacin (10–5 M) (n = 8) and verapamil (10–6) (n = 8) were recorded. Responses elicited with cumulative H2O2 in Ca2+ free extracellular medium and the responses to cumulative Ca2+ (10–4 M-2 × 10–3 M) after H2O2 (10–3 M) induced contraction were also studied. The Emax for each experiment was calculated. p
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