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Vectors for Inhaled Gene Therapy in Lung Cancer. Application for Nano Oncology and Safety of Bio Nanotechnology

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Author(s): Paul Zarogouldis | Nikos K. Karamanos | Konstantinos Porpodis | Kalliopi Domvri | Haidong Huang | Wolfgang Hohenforst-Schimdt | Eugene P. Goldberg | Konstantinos Zarogoulidis

Journal: International Journal of Molecular Sciences
ISSN 1422-0067

Volume: 13;
Issue: 9;
Start page: 10828;
Date: 2012;
Original page

Keywords: lung cancer | inhaled gene therapy | non-viral vectors | nanocomplexes | nanobiotechnology

ABSTRACT
Novel aerosol therapeutic modalities have been investigated for lung cancer. Inhaled gene therapy has presented safety and effectiveness previously in cystic fibrosis. However, safety concerns have been raised regarding the safety of non-viral vectors for inhaled gene therapy in lung cancer, and therefore small steps have been made towards this multifunctional treatment modality. During the last decade, numerous new nanocomplexes have been created and investigated as a safe gene delivery nano-vehicle. These formulations are multifunctional; they can be used as either local therapy or carrier for an effective inhaled gene therapy for lung cancer. Herein, we present current and future perspectives of nanocomplexes for inhaled gene therapy treatment in lung cancer.
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