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Verapamil Ameliorates Cardioprotective Potential of Vitamin E in Myocardial Oxidative Damage Induced by Isoproterenol: A Biochemical Study

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Author(s): Shikalgar T.S | Naikwade.N.S

Journal: Journal of Pharmaceutical Science and Technology
ISSN 0975-5772

Volume: 2;
Issue: 9;
Start page: 298;
Date: 2010;
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Keywords: Isoprotereno | Verapamil | Vitamin E | Cardiotoxicity.

ABSTRACT
Cardiotoxicity resulted from exposure to the environmental toxicants, drugs, pesticides, and even food additives and pollutants have been known for a long time. Chemicals can induce persistent molecularchanges with functional consequences without leading to morphologically detectable alterations. Depending on dosage and duration of the exposure to toxic substances, functional changes may be less serious and of transient nature, but they may also irreversible. Since functional effects are frequently of acute nature, they may quickly lead to abnormal heart function, which may be fatal..Present study aimed to evaluate amelioration of cardioprotective effect of Vitamin E by Verapamil. Albino rats were orally treated with different combinations of Verapamil and Vitamin E orally for 30 days. On the day 29th and 30th, Isoproterenol was administered S.C. Different biochemical parameters were screened from serum and heart preparation. The present study concluded that the subtherapeutic doses combinations of Verapamil and vitamin E prevent cardiac damage significantely.
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