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Virulence factors of Staphylococcus aureus and Pseudomonas aeruginosa strains involved in the etiology of cardiovascular infections

Author(s): Otilia Banu | Coralia Bleotu | Mariana Carmen Chifiriuc | Bogdan Savu | George Stanciu | Cristina Antal | Magdolna Alexandrescu | Veronica Lazǎr

Journal: Biointerface Research in Applied Chemistry
ISSN 2069-5837

Volume: 1;
Issue: 2;
Start page: 72;
Date: 2011;
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Keywords: cellular substrate | prosthetic devices | virulence factors | bacterial adherence | invasion

The purpose of tihis study was to investigate by in vitro methods the capacity of adhesion and invasion to cellular and inert substrata, as well as the invasive properties of some Staphylococcus aureus and Pseudomonas aeruginosa strains isolated from various clinical specimens in patients with cardiovascular infections. Strains isolation and identification was performed using API galleries and the automatic Vitek II system. The selected strains have been phenotypically evaluated for the adherence to the cellular substrate represented by HeLa cells, adherence to the inert substrate quantified by slime test and a serios of soluble virulence factors (lechitinase, lipase, amylase, caseinase, gelatinase, DN-ase, haemolysins). The isolated strains exhibited an evident tendency of colonizing the cellular and inert substrate, also harboring enzymes with role in the invasion of host tissues and thus susceptible to produce systemic infections.
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