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Visfatin polymorphism may increase tendency to diabetic nephropathy

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Author(s): Serap Demir | Asuman Özgöz | Fadime Mutlu İçduygu | Kuyaş Hekimler | Tülay Köken | Necat İmirzalıoğlu

Journal: Nephrology Reviews
ISSN 2035-8261

Volume: 4;
Issue: 1;
Start page: e4;
Date: 2012;
Original page

Keywords: diabetes complications | diabetic nephropathies | polymorphism | nicotinamide phosphoribosyltransferase | single nucleotide

ABSTRACT
Visfatin is a novel adipocytokine, which is suggested to play a role in kidney diseases. We hypothesized that diabetics with diabetic nephropathy may have a different gene profile and this study was performed to evaluate the association between visfatin gene promoter region SNPs and diabetic nephropathy. Realtime PCR was used to study SNPs (1001T/G, 423A/G, 1535C/T) of the visfatin gene promoter region in 30 type 2 diabetics with nephropathy, 30 type 2 diabetics without nephropathy, and 30 healthy volunteers who served as control. Routine biochemical parameters, serum insulin, TNF-α, urinary protein and microalbumine were tested in subjects. Insulin resistance was evaluated by the HOMA method. Non-heterozygotes for the SNPs 423 A/G and 1001 T/G had significantly less risk of having nephropathy (for each group odds ratio 0.181 with 95% confidence interval:0.048-0.674). They also had lower serum visfatin levels than subjects with AA and TT genotypes (P=0.035 and P=0.030, respectively). We could not find any relationship between genotype and gender, BMI, HOMA-IR score, HbA1c, proteinuria, serum lipid and TNF-α levels. The two SNPs, 1001 T/G and 423 A/G were in perfect linkage disequilibrium. We, therefore, suggest that visfatin gene polymorphisms may increase the tendency to diabetic nephropathy.
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