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In vitro anti-inflammatory activity of Mangrove associated fungi

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Author(s): Elsa Lycias Joel* and B.Valentin Bhimba

Journal: Journal of Pharmacy Research
ISSN 0974-6943

Volume: 4;
Issue: 9;
Start page: 2900;
Date: 2011;
Original page

Keywords: Marine fungi | Mangrove | anti-inflammatory | ITS sequence

ABSTRACT
Medicinal plants such as mangroves have received attention as supplements to treat various conditions or to promote general health and well-being. Theseplants also represent a valuable resource of fungi with an array of compounds that may have utility as new therapeutic agents. Mangrove endophytic fungi withanti-inflammatory activity have been considerably employed in the traditional treatment of several disorders of inflammation. The prevention of hypotonicityinduced HRBC membrane lysis was taken as a measure of anti-inflammatory activity. The solvent extracts of the foliar fungi was screened for antiinflammatoryactivity. All the extract showed a biphasic effect on the membrane stabilization. Their activities are comparable to that of standard drugIndomethacin. And hunting for new non steroidal anti inflammatory compounds is of high significance. So, the present study was undertaken to establishscientific evidence for anti-inflammatory and membrane-stabilizing property of ethyl acetate extracts of fungi.
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