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In vitro Antimicrobial Assessment of Lepidium sativum L. Seeds Extracts

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Author(s): Shama I.Y. Adam | Shayma A.M. Salih | Warda S. Abdelgadir

Journal: Asian Journal of Medical Sciences
ISSN 2040-8765

Volume: 3;
Issue: 6;
Start page: 261;
Date: 2011;
Original page

Keywords: Antimicrobial activity | C. albicans | E. coli | K. pneumonae | Lepidium sativum | P. vulgaris | P. aeruginosa | S. aureus

ABSTRACT
The antimicrobial activity of the petroleum ether, methanol and water extracts of Lepidium sativum seed extracts against six opportunistic pathogens namely Staphylococcus aureus, Escherichia coli, Klebsiella pneumonae, Proteus vulgaris, Pseudomonas aeruginosa and one fungus Candida albicans was assessed using the concentrations of 2.5, 5 and 10%. The antimicrobial activity of plant seeds extracts were compared with that of Gentamicin or Ketoconzol, as reference antibiotics. The petroleum ether extract of Lepidium sativum seeds in different concentrations (2.5-5-10%) were found to be active antimicrobials against all the test microorganisms with a strong antifungal activity at the concentration 2.5 and 10%. At the concentration of 5%, the methanolic extract of this plant had no activity against Candida albicans. Staphylococcus aureus and Candida albicans were resistant to 2.5 and 5% water extracts, whereas the latter was also resistant to 5% methanolic extract. The antimicrobial activity of Gentamicin and Ketoconzol against the same test microorganisms was compared with that of the extracts of L. sativum seeds.
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