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In vitro Antimicrobial and Cytotoxic Activities of Ferrocene Derivative Compounds

Author(s): M. Abdul Alim Al-Bari | M. Faruk Hossen | Alam Khan | M. Robiul Islam | M. Kudrat-E-Zahan | M. Ashik Mosaddik | Choudhury M. Zakaria | M. Anwar Ul Islam

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 10;
Issue: 15;
Start page: 2423;
Date: 2007;
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Keywords: Ferrocene derivatives | antimicrobial activity | Artemia salina L

The aim of the present study was to investigate the biocidal activity of four new ferrocene derivative based coordination complexes, [1,2,3-trithia-|3|-ferrocenophane, C1]; [disodium-1,1’-ferrocenedithiolate, C2]; [1,1’-(ferrocene-1,1’-diyl)-diethanol, C3]; [ferrocenyl(ethyl-phenyl)-methanol, C4]; against microbes (bacteria and fungi) and brine shrimp (Artemia salina Lech.) nauplii. C2 showed modest antibacterial activity at the concentration of 200 μg disc-1 and gave its Minimum Inhibitory Concentration values at 32-64 μg mL-1 against the tested bacteria. These complexes gave comparatively better antibacterial activity against the Gram-positives than the Gram-negatives. C3, C1 and C4 showed moderate antifungal activity at concentration of 200 μg disc-1. Brine shrimp eggs were hatched in artificial sea water and exposed to the complexes. Median lethal concentration (LC50) values were calculated. Both complexes showed toxicity against brine shrimp but complex C3 explored its potent cytotoxicity having LC50 values at 6.031 μg mL-1 (ppm).

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