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In vitro Antimicrobial Screening of Three Cadmium Coordination Complexes and Two Addition Compounds of Antimony and Arsenic

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Author(s): Chand Sultana | M. Aziz Abdur Rahman | M.A.A. Al-Bari | M.L.A. Banu | M. Saidul Islam | N. A. Khatune | Golam Sadik

Journal: Pakistan Journal of Biological Sciences
ISSN 1028-8880

Volume: 6;
Issue: 5;
Start page: 525;
Date: 2003;
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Keywords: Coordination complexes | antimicrobial activity | antifungal activity | pathogens

ABSTRACT
Three cadmium coordination complexes (cadmium deprotonated phthalyl pyridine [Cd(DPH)(Py)2, C1], cadmium deprotonated phthalyl 8-hydroxy quinoline [Cd(DPH)-8-HQ, C2] & cadmium deprotonated phthalyl isoquinoline [Cd(DPH)IQ, C3] and two addition compounds 1:1 antimony(III) chloride with acetophenone [SbCl3.C6H5COCH3, C4] & 1:1 arsenic(III)bromide with benzamide [AsBr3.C6H5CONH2, C5] were tested for their antimicrobial activity by disc diffusion and serial dilution methods. All the compounds were active against various test pathogenic organisms. The maximum antibacterial and antifungal activities were shown by the compound C4. The minimum inhibitory concentration (MIC) of the compound C4 was determined against two Gram positive (Bacillus subtilis and Streptococcus ß-haemolyticus) and two Gram negative (Shilgella dysenteriae, Salmonella typhi) bacteria and the values were found between 4 and 16 �g ml-1.
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