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In vitro antiviral activity of antimicrobial peptides against herpes simplex virus 1, adenovirus, and rotavirus

Author(s): Márcia Cristina Carriel-Gomes | Jadel Müller Kratz | Margherita Anna Barracco | Evelyne Bachére | Célia Regina Monte Barardi | Cláudia Maria Oliveira Simões

Journal: Memórias do Instituto Oswaldo Cruz.
ISSN 0074-0276

Volume: 102;
Issue: 4;
Start page: 469;
Date: 2007;
Original page

Keywords: antimicrobial peptides | antiviral activity | herpesvirus | adenovirus | rotavirus

Peptides with broad-spectrum antimicrobial activity, known as antimicrobial peptides, have been isolated from distinct organisms. This paper describes the in vitro evaluation of the cytotoxicity and antiviral activity of nine peptides with different structures and origins against herpes simplex virus type 1, human adenovirus respiratory strain, and rotavirus SA11. Most of the evaluated peptides presented antiviral activity but they were only active near cytotoxic concentrations. Nevertheless, these results seem promising, and further modifications on the peptide's structures may improve their selectivity and reduce their cytotoxicity.
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