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In Vitro Cytotoxic Activity of Origanum vulgare L. on HCT-116 and MDA-MB-231 Cell Lines

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Author(s): Filip Grbović | Milan S. Stanković | Milena Ćurčić | Nataša Đorđević | Dragana Šeklić | Marina Topuzović | Snežana Marković

Journal: Plants
ISSN 2223-7747

Volume: 2;
Issue: 3;
Start page: 371;
Date: 2013;
Original page

Keywords: antiproliferative activity | HCT-116 | MDA-MB-231 | Origanum vulgare L.

ABSTRACT
In the present investigation, we examined the cytotoxic effect of methanolic extract from Origanum vulgare on HCT-116 and MDA-MB-231 cell line in vitro. In order to determine the cytotoxic effects we used an MTT viability assay. The results showed that cell growth is significantly lower in extract treated cells compared to untreated control. The effect of inhibition of cell growth was higher in the treatment of HCT-116 cell line than in MDA-MB-231. Based on the results it is determined that O. vulgare is a significant source of biologically active substances that have cytotoxic and antiproliferative activity in vitro.
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