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In vitro evaluation of antiperoxidative potential of water extract of Spirulina platensis (blue green algae) on cyclophosphamide-induced lipid peroxidation

Author(s): Ray S | Roy K | Sengupta Chandana

Journal: Indian Journal of Pharmaceutical Sciences
ISSN 0250-474X

Volume: 69;
Issue: 2;
Start page: 190;
Date: 2007;
Original page

The aim of the study is to evaluate free radical scavenging activity of water extract of Spirulina platensis on cyclophosphamide-induced lipid peroxidation using some common laboratory markers. In this study goat liver has been used as liver source. This in vitro evaluation was done by measuring the malondialdehyde, 4-hydroxy-2-nonenal, reduced glutathione and nitric oxide content of tissue homogenates. The results suggest that cyclophosphamide could induce lipid peroxidation to a significant extent and it was also found that water extract of the algae has the ability to suppress the drug-induced lipid peroxidation.

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