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IN VITRO EVALUATION OF GASTRO-PROTECTIVE ACTIVITY OF SURAN - A POSSIBLE EXPLANATION THROUGH HPTLC ANALYSIS

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Author(s): H.N. Nataraj | R.L.N. Murthy | S.Ramachandra Setty

Journal: International Research Journal of Pharmacy
ISSN 2230-8407

Volume: 2;
Issue: 9;
Start page: 103;
Date: 2011;
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Keywords: Amorphophallus paeoniifolius | gastroprotection | pylorus ligation ceration | Biochemical parameters | GSH | LPO | Lansoprazole

ABSTRACT
Gastrointestinal ulcerogenesis has been reported as various free radical species mediated. There by free radical scavengers can play an important role in such diseases. The Methanolic Extract of Suran – Corms of Amorphophallus paeoniifolius (MECAP) exhibited remarkable anti-oxidant activity in various In-vitro models. Further, preliminary phytochemical screening revealed the presence of polyphenolic compounds which are known to possess anti-ulcer activity. In light of these finding, it was considered worth while to investigate the gastroprotective activity of MECAP against pylorus ligation induced gastotoxicity in albino rats. Biochemical parameters like volume of gastric secretion, PH, Free and Total Acidity, Ulcer Index, and in vitro estimation of GSH and LPO were studied. MECAP showed significant reduction in the elevated gastric parameters in dose dependent manor along with significant restoration of protective-GSH levels and suppression of LPO levels in tissues, in comparison with Standard Lansoprazole. It was concluded that gastroprotective effect possessed by MECAP may be offered by bioactive constituents mainly the nine polyphenolics revealed in HPTLC analysis.
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