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In vitro glucose uptake by isolated rat hemi-diaphragm study of Aegle marmelos Correa root

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Author(s): Subban Ravi | C.T. Sadashiva | T. Tamizmani | T. Balasubramanian | M. Rupeshkumar | Indira Balachandran

Journal: Bangladesh Journal of Pharmacology
ISSN 1991-007X

Volume: 4;
Issue: 1;
Start page: 65;
Date: 2009;
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Keywords: Aegle marmelos | Anti-diabetic activity | 6-methyl-4-chromanone | Skimmianine

ABSTRACT
The methanol extract of the root of Aegle marmelos, a medicinal plant, was fractionated into eight fractions using column chromatography. The anti-diabetic activity of all the fractions was studied using the glucose uptake by isolated rat hemi-diaphragm in vitro model. Using the bioassay-guided fractionation, two compounds 1 and 2 were isolated by column chromatography and identified as 6-methyl-4-chromanone and skimmianine respectively by NMR and mass spectral methods.
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