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In Vitro Lipid Peroxidation and Antimicrobial Activity of Mucuna Pruriens Seeds

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Author(s): Yerra Rajeshwar | Malaya Gupta | Upal Kanti Mazumder

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 4;
Issue: 1;
Start page: 32;
Date: 2005;
Original page

Keywords: Mucuna pruriens seeds | In vitro lipid peroxidation | Antimicrobial activity

ABSTRACT
The present investigation is aimed to carry out the in vitro lipid peroxidation and antimicrobial activities of the methanol extract of Mucuna pruriens (MEMP) (Family: Fabaceae) seeds. Lipid peroxidation was monitored by the change in optical density of the prepared concentrations (10-320 g/ml) and the % inhi-bition was calculated. Ascorbate/FeSO4-induced peroxidation was inhibited by standard antioxidants such as quercetin, L-ascorbic acid and MEMP. Moreover, the % inhibition of the methanol extract increased with increase in concentration. IC50 value for the MEMP, L-ascorbic acid and quercetin for lipid peroxida-tion was found to be 217.25 g/ml, 41 g/ml and 19.75 g/ml respectively. The antimicrobial activity of MEMP was determined by disc diffusion method with various Gram positive and Gram-negative microor-ganisms. MEMP showed broad-spectrum antimicrobial activity against all the tested microorganisms ex-cept Staphylococcus aureus ML 152 and Vibrae cholera 14035. The results obtained in the present study indicate that MEMP can be a potential source of natural antioxidant and antimicrobial agent.
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