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In Vitro Lipid Peroxidation Inhibitory and Antimicrobial Activity of Phyllanthus Niruri (Euphorbiaceae) Extract

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Author(s): yerra rajeshwar | Rayees Ahmad | A. Shyam Sunder | J. Devilal, Malaya Gupta | Upal Kanti Mazumder

Journal: Iranian Journal of Pharmacology and Therapeutics
ISSN 1735-2657

Volume: 7;
Issue: 1;
Start page: 67;
Date: 2008;
Original page

Keywords: Phyllanthus niruri | In vitro lipid peroxidation inhibitory activity | Antimicrobial activity

ABSTRACT
The present work was designed to evaluate the in vitro lipid peroxidation inhibitory and antimicrobial activities of the methanol extract of Phyllanthus niruri (MEPN) (Family: Euphorbiaceae). Lipid peroxidation was measured by the optical density of the prepared solutions (10-320 µg/ml) and then the percent inhibition was calculated. Ascorbate/FeSO4-induced peroxidation was inhibited by standard antioxidants such as L-ascorbic acid, Quercetin and MEPN. Moreover, the percent inhibition of the methanol extract was increased in a concentration-dependent manner. IC50 value for the MEPN, L-ascorbic acid and Quercetin for lipid peroxidation was found to be 62.5 µg/ml, 41 µg/ml and 19.75 µg/ml respectively. The antimicrobial activity of MEPN was determined by disc diffusion method with various gram positive and gram-negative microorganisms. The MEPN showed strong antimicrobial activity against Bacillus pumillus 8241, Bacillus cereus, Escherichia Coli 54B and Vibrae Cholera at a concentration of 750mg/ml/disc. However, its activity against Staphylococcus aureus ML 152 and Vibrae cholera 14035 was less significant. The antimicrobial activity of the extract was compared with the standard drug, Chloramphenicol at a concentration of 10mg/ml/disc. The results obtained in the present investigation clearly suggest that MEPN can be a potential source of natural antioxidant and antimicrobial agent.

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