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IN VITRO AND IN VIVO ANTIOXIDANT POTENTIAL OF ETHANOLIC EXTRACT OF SYZYGIUM JAMBOS (L.) BARK

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Author(s): Md. Rafikul Islam | Mst. Shahnaj Parvin | Md. Obayed Raihan | S. M. Raquibul Hasan | Md. Ekramul Islam

Journal: International Journal of Research in Ayurveda and Pharmacy
ISSN 2229-3566

Volume: 2;
Issue: 3;
Start page: 810;
Date: 2011;
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Keywords: SJB | Ethanolic Extract | Antioxidant Activity.

ABSTRACT
Antioxidants are vital substances which possess the ability to protect the body from damage caused by free radical induced oxidative stress. A variety of free radical scavenging antioxidants exist within the body, many of them are derived from dietary sources like fruits, vegetables and teas. In this study the antioxidant activity of the ethanolic extract of Syzygium jambos bark (SJB) was investigated for antioxidant potential. The in-vitro antioxidant activities of the extract was evaluated by DPPH free radical scavenging assay, total antioxidant capacity, reducing power capacity, total phenol and total flavonoid content. The extract demonstrated significant dose dependent antioxidant activity. The extract of SJB was evaluated for in vivo efficacy by carbon tetrachloride (CCl4) induced liver damage rats in hepatoprotective model. CCl4 produced significant alteration of serum marker enzymes, total bilirubin, total protein and liver weight. Restoration of these values towards normal which is comparable to control group indicated hepatoprotective potential of the extract. The free radical scavenging and antioxidant activities may be attributed to the presence of phenolic and flavonoid compounds present in SJB. Due to its natural origin and potent free radical scavenging ability SJB could be used as a potential preventive intervention for free radical mediated diseases.
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