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Volumetry of the Thalamus in Idiopathic Generalized Epilepsy

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Author(s): Zeynep | Ege | Serra | Betül

Journal: Nöropsikiyatri Arşivi
ISSN 1300-0667

Volume: 46;
Issue: 4;
Start page: 243;
Date: 2011;
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Keywords: Idiopathic generalized epilepsy | absence seizure | thalamus | thalamometric analysis

ABSTRACT
Objective: Studies aiming to explain the pathophysiology of idiopathic generalized epilepsy (IGE) indicate that the epileptic activity arises from thalamocortical circuitry. The aims of this study were to explore the pathophysiology of IGE using the thalamic volume measurements and to compare the measurement results between subsyndromes of IGE, between different seizure types and between the presence/absence of absence status epilepticus and, finally, to evaluate the effect of the possible differences on pathogenetic mechanisms of IGE. Met­hods: We investigated thirty-one patients followed up by the Department of Neurology - Epilepsy Center at Istanbul University, Istanbul Faculty of Medicine with the diagnosis of IGE according to the International League Against Epilepsy (ILAE) classification and 15 age- and sex-matched healthy volunteers. The borders of the thalamus and total brain were marked manually by using ‘DicomWorks software’ in coronal sections and, volumetric analysis was done. The values in the patients with IGE were compared with those in the normal controls using appropriate statistical tests. Re­sults: There were no statistically significant differences between the left, right and total thalamic volumes in relation to the total brain volume in patients and controls. However, thalamic volume was found to be increased in IGE patients with absence seizures in comparison to those without absences. Conc­lu­si­on: These results support the hypothesis that thalamus plays an important role in the pathophysiology of the absence seizures. (Arc­hi­ves of Neu­ropsy­chi­atry 2011; 48: 243-8)
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