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Water Balance and Serum Levels of Some Electrolytes in Oral Contraceptive-Treated Female Wistar Rats

Author(s): R.E. Akhigbe | S.F. Ige | A.O. Afolabi | P.I. Oyeyipo | F.O. Ajao | F.A. Ajayi

Journal: Journal of Medical Sciences
ISSN 1682-4474

Volume: 8;
Issue: 6;
Start page: 591;
Date: 2008;
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Keywords: Water consumption | urinary output | plasma electrolytes | oral contraceptive

This study was designed to investigate the effect of combined oral contraceptive (OC) on water consumption, urinary output and serum levels of sodium, potassium and calcium. Twenty female rats were used. Rats were distributed into two groups, control and OC-treated groups, with ten rats in each group. OC-treated group took combined OC, containing 1.0 μg ethinyloestradiol and 10.0 μg norgestrel intragastrically for nine weeks. Both groups fed on standard rat chow and were allowed free access to water throughout the nine weeks of experiment. Water consumption and urinary output was noted and recorded during the experiment period. After the experiment period, rats were sacrificed and serum levels of sodium and potassium were determined in both groups using the flame photometry method, while serum calcium level was determined in both groups using cresolphthalein complexone. There was significant decrease in water consumption and urinary output. No significant differences were found in the mean serum levels of sodium, potassium and calcium.

Tango Jona
Tangokurs Rapperswil-Jona

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