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Author(s): Tatjana Radjenovic - Petkovic | Milan Radovic | Tatjana Pejcic | Milan Rancic | Desa Nastasijevic | Ivanka Djordjevic

Journal: Acta Medica Medianae
ISSN 0365-4478

Volume: 47;
Issue: 3;
Start page: 78;
Date: 2008;
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Keywords: Wegener granulomatosis | lung involvement | ANCA

Wegener granulomatosis is uncommon multisystemic disease, characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tracts and general focal necrotizing vasculitis (Commonly known as „Wegener's triad“). The lungs are involved in 72 per cent of patients and the clinic and radiographic findings indicated bilateral pulmonary nodules of varying size and definition, cavitated in half of the patients, accompanied by the nodular lesion with a rare involvement of the pleura.We described a case of 62-year-old women with pansinusitis, mild azotemia and initial respiratory tract symptoms such as chronic cough and occasional hemoptysis. Due to bilateral nodular infiltrates in lungs on chest radiogram she was initially treated for smear negative pulmonary tuberculosis, but without expected antituberculous response. An additional diagnostic procedure pointed to Morbus Wegener.Two patterns of ANCA positive immunofluorescence are recognized as reliable and valuable diagnostic tools in the absence of histopathology for the diagnosis of Wegener granulomatosis.

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