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What Shapes Depressed Individuals' Pre-Treatment Expectation in Antidepressant Clinical Trials?

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Author(s): Tally Moses | Andrew F. Leuchter | Ian Cook | Michelle Abrams

Journal: The Internet Journal of Mental Health
ISSN 1531-2941

Volume: 3;
Issue: 2;
Date: 2007;
Original page

Keywords: Depression | Antidepressive Agents | Second-Generation | Clinical Trials | Personality Assessment | Locus of Control

ABSTRACT
Objective: To examine the relationship between patients' treatment outcome expectation and a set of socio-demographic factors, clinical course variables, symptom severity, health locus of control, and Temperament and Character Inventory (TCI) dimensions. Method: Logistic regression analyses were performed on data collected at screen and baseline interviews from 45 participants enrolled into one of two randomized placebo controlled antidepressant trials. Results: Participants with high outcome expectations reported shorter depressive episodes and scored lower on Harm Avoidance (TCI). The data also suggest that external locus of control, gender, ethnicity/race, employment status, and the dimension of self-directedness (TCI) may have a role in shaping treatment expectation. Conclusion: Depressed patients' treatment outcome expectations were found to be associated with depression characteristics, personality traits, locus of control, and certain socio-demographic factors. If these findings are replicated, this information can be used to identify individuals needing additional interpersonal support or motivation at the onset of treatment.
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