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Y-haplotypes and idiopathic male infertility in an Indian population

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Author(s): Singh Kiran | Raman Rajiva

Journal: Indian Journal of Human Genetics
ISSN 0971-6866

Volume: 15;
Issue: 1;
Start page: 19;
Date: 2009;
Original page

Keywords: Male infertility | single nucleotide polymorphism | Y-haplotypes

ABSTRACT
Infertility being a multifactorial disorder, both genetic and environmental factors contribute to the etiology of infertile phenotype. Chromosomal anomalies and Y-microdeletion are the established genetic risk factors of male infertility. Y-haplotypes has been found as risk factor for male infertility in certain populations, though in certain others no association has been reported, suggesting a population-specific association of these variations with male infertility. In a case-control study, 165 azoo-/oligospermic patients and 200 controls were haplotyped for certain Y-haplogroups for a possible association with idiopathic male infertility in an Indian population. Analysed Y-haplogroups showed no association with infertile phenotype. Thus this genetic factor is not a risk for infertility in the studied Indian population but that does not rule out the possibility of any of them, to be a risk in other populations.
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