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Zaburzenia funkcji poznawczych u chorych z przewlekłym wirusowym zapaleniem wątroby typu C

Author(s): Wiktor Dróżdż | Waldemar Halota | Elwira Palewicz | Dorota Kozielewicz | Dorota Dybowska | Alina Borkowska

Journal: Neuropsychiatria i Neuropsychologia
ISSN 1896-6764

Volume: 3;
Issue: 3-4;
Start page: 126;
Date: 2008;
Original page

Keywords: chronic hepatitis C | cognitive dysfunctions | age

Background: Both presence and replication activity ofthe hepatitis C virus in brains of patients with chronichepatitis C (CHC) were revealed. A significant proportionof CHC patients demonstrate cognitive abnormalities.The purpose of this exploratory study was an assessmentof the specificity and frequency of cognitive dysfunctionsand also clinical and demographical factors associatedwith cognitive deficits in CHC patients.Material and methods: Adult CHC patients withcompensated liver function, without current or pastpsychotic disorder, bipolar disorder, substance abuse oran organic brain damage were enrolled. Demographicand clinical data were collected from CHC patients andfrom control healthy subjects. Brief neuropsychologicalbattery consisted of the TMT A+B and the Stroop TestA+B. Neuropsychological performance was comparedwithin age subgroups (18-29, 30-39, 40-49 and 50-60years). The cut-off point of >2 standard deviations (SD)was used for qualifying a result as markedly worse thanthat of healthy control subjects.Results: 239 CHC patients aged 18-60 years and 170healthy subjects adjusted for age and education levelwere recruited. Patients performed significantly worseon all cognitive measures in every age subgroup.Between 21% and 34% of CHC patients, depending onthe measure, had substantial (>2 SD) cognitivedysfunctions. No correlation was found betweencognitive performance and either staging or grading inliver biopsy in CHC patients.Conclusions: Significant abnormalities of workingmemory and executive functions were present in at least20% of CHC patients with compensated liver functionwithin all age clusters. This may influence psychosocialfunctioning of the patients.
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