Academic Journals Database
Disseminating quality controlled scientific knowledge

Zingiber officinale acts as a nutraceutical agent against liver fibrosis

ADD TO MY LIST
 
Author(s): Motawi Tarek | Hamed Manal | Shabana Manal | Hashem Reem | Aboul Naser Asmaa

Journal: Nutrition & Metabolism
ISSN 1743-7075

Volume: 8;
Issue: 1;
Start page: 40;
Date: 2011;
Original page

Keywords: Zingiber officinale | liver fibrosis | enzymes | antioxidants | histology

ABSTRACT
Abstract Background/objective Zingiber officinale Roscoe (ginger) (Zingiberaceae) has been cultivated for thousands of years both as a spice and for medicinal purposes. Ginger rhizomes successive extracts (petroleum ether, chloroform and ethanol) were examined against liver fibrosis induced by carbon tetrachloride in rats. Results The evaluation was done through measuring antioxidant parameters; glutathione (GSH), total superoxide dismutase (SOD) and malondialdehyde (MDA). Liver marker enzymes; succinate and lactate dehydrogenases (SDH and LDH), glucose-6-phosphatase (G-6-Pase), acid phosphatase (AP), 5'- nucleotidase (5'NT) and liver function enzymes; aspartate and alanine aminotransferases (AST and ALT) as well as cholestatic markers; alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), total bilirubin were estimated. Liver histopathological analysis and collagen content were also evaluated. Treatments with the selected extracts significantly increased GSH, SOD, SDH, LDH, G-6-Pase, AP and 5'NT. However, MDA, AST, ALT ALP, GGT and total bilirubin were significantly decreased. Conclusions Extracts of ginger, particularly the ethanol one resulted in an attractive candidate for the treatment of liver fibrosis induced by CCl4. Further studies are required in order to identify the molecules responsible of the pharmacological activity.
Affiliate Program      Why do you need a reservation system?