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EGFR Mutations Detection in Non-small Cell Lung Cancer Tissues by Real-time PCR and DNA Sequencing

Author(s): Yongwen LI | Hongyu LIU | Ying LI | Yuli WANG | Jing WANG | Jun CHEN | Qinghua ZHOU
Role of erlotinib in first-line and maintenance treatment of advanced non-small-cell lung cancer

Author(s): Noemí Reguart | Andrés Felipe Cardona | Rafael Rosell
Current status of vandetanib (ZD6474) in the treatment of non-small cell lung cancer

Author(s): Jaclyn Flanigan | Hari Deshpande | Scott Gettinger
Erlotinib in the treatment of advanced pancreatic cancer

Author(s): Robin K Kelley | Andrew H Ko
KRAS Mutations and Primary Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib

Author(s): Pao William | Wang Theresa Y | Riely Gregory J | Miller Vincent A | Pan Qiulu | Ladanyi Marc | Zakowski Maureen F | Heelan Robert T | Kris Mark G | Varmus Harold E
The epidermal growth factor receptor (EGFR) in head and neck cancer: its role and treatment implications

Author(s): Zimmermann Michel | Zouhair Abderrahim | Azria David | Ozsahin Mahmut
A novel small molecule that selectively inhibits glioblastoma cells expressing EGFRvIII

Author(s): Trembath Dimitri | Lal Anita | Kroll David | Oberlies Nicholas | Riggins Gregory
K-RAS Gene Mutations in Patients with Non-small Cell Lung Cancer

Author(s): Yang ZHANG | Zhenkui PAN | Xing ZHANG | Fei XU | Li ZHANG
Lack of Cetuximab induced skin toxicity in a previously irradiated field: case report and review of the literature

Author(s): Kanakamedala Madhava | Packianathan Satyaseelan | Vijayakumar Srinivasan
Comparison of EGFR Mutation Status in Paired Pre- and Post-chemotherapy Serum for Advanced Pulmonary Adenocarcinoma

Author(s): Rubing HAN | Wei ZHONG | Jing ZHAO | Li ZHANG | Ying XIA | Han WANG | Longyun LI | Mengzhao WANG
Acneiform Eruption due to Cetuximab Therapy: A Case Report

Author(s): Özer Arıcan | Neşe Önver
Role of purinergic receptors in the activation of human airway smooth muscle cells by the antimicrobial peptide LL-37

Author(s): Suzanne Zuyderduyn | Dennis. K. Ninaber | Pieter. S. Hiemstra | Klaus. F. Rabe
Response to gefitinib and erlotinib in Non-small cell lung cancer: a retrospective study

Author(s): Emery Ivette | Battelli Chiara | Auclair Paul | Carrier Kathleen | Hayes Daniel
The drug-resistance to gefitinib in PTEN low expression cancer cells is reversed by irradiation in vitro

Author(s): Zhuang Hong-Qing | Wang Jun | Yuan Zhi-Yong | Zhao Lu-Jun | Wang Ping | Wang Chang-Li
Evaluation of 7q31 region improves the accuracy of EGFR FISH assay in non small cell lung cancer

Author(s): Casorzo Laura | Corigliano Mara | Ferrero Paolo | Venesio Tiziana | Risio Mauro
Detection and Its Clinical Significance of EGFR Gene Mutation and Gene Amplification in 187 Patients with Non-small Cell Lung Cancer

Author(s): Hongyu LIU | Ying LI | Gang CHEN | Jing WANG | Yongwen LI | Yuli WANG | Sen WEI | Daxing ZHU | Xiaoming QIU | Weiqiang WAN | Zuoqing SONG | Jun CHEN | Qinghua ZHOU
Exons 19 and 21 of Epidermal Growth Factor Receptor Are Highly Conserved in Squamous Cell Cancer of the Head and Neck

Author(s): Matthew Carlson | Beverly Wuertz | Jizhen Lin | Randy Taylor | Frank Ondrey
Management of chronic allograft dysfunction by switch over to rapamycin

Author(s): Sundaram Varun | Abraham Georgi | Fathima Nusrath | Sundaram Vivek | Reddy Yogesh | Mathew Milly | Sathiah Vijaiaboobbathi
SplicerAV: a tool for mining microarray expression data for changes in RNA processing

Author(s): Robinson Timothy | Dinan Michaela | Dewhirst Mark | Garcia-Blanco Mariano | Pearson James
Synergistic effect of gefitinib and rofecoxib in mesothelioma cells

Author(s): Stoppoloni Daniela | Canino Claudia | Cardillo Irene | Verdina Alessandra | Baldi Alfonso | Sacchi Ada | Galati Rossella
Hemorrhage of brain metastasis from non-small cell lung cancer post gefitinib therapy: two case reports and review of the literature

Author(s): Yan Dan-Fang | Yan Sen-Xiang | Yang Jing-Song | Wang Yi-Xiang | Sun Xiao-Li | Liao Xin-Biao | Liu Jun-Qing
Severe Skin Lesions in Patients with Glioblastoma Multiforme Treated with a Combination of Cetuximab, Bevacizumab, and Irinotecan

Author(s): Morten Sorensen | Tine Bernhardtsen Gaziel | Benedikte Hasselbalch | Hans Skovgaard Poulsen | Ulrik Lassen
Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer

Author(s): Sánchez-Muñoz Alfonso | Gallego Elena | de Luque Vanessa | Pérez-Rivas Luís | Vicioso Luís | Ribelles Nuria | Lozano José | Alba Emilio
Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition

Author(s): Corso Simona | Ghiso Elena | Cepero Virna | Sierra J Rafael | Migliore Cristina | Bertotti Andrea | Trusolino Livio | Comoglio Paolo | Giordano Silvia
Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma

Author(s): Wernicke A Gabriella | Dicker Adam | Whiton Michal | Ivanidze Jana | Hyslop Terry | Hammond Elizabeth | Perry Arie | Andrews David | Kenyon Lawrence
EGFR Targeting in Hormone-Refractory Prostate Cancer: Current Appraisal and Prospects for Treatment

Author(s): Olivier Guérin | Jean Louis Fischel | Jean-Marc Ferrero | Alexandre Bozec | Gerard Milano
Phospholipase D2 Enhances Epidermal Growth Factor-Induced Akt Activation in EL4 Lymphoma Cells

Author(s): Manpreet S. Chahal | Daniel J. Brauner | Kathryn E. Meier
Receptor-Based Virtual Screening of EGFR Kinase Inhibitors from the NCI Diversity Database

Author(s): Kiattawee Choowongkomon | Orathai Sawatdichaikul | Napat Songtawee | Jumras Limtrakul
MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation

Author(s): Meierjohann Svenja | Hufnagel Anita | Wende Elisabeth | Kleinschmidt Markus | Wolf Katarina | Friedl Peter | Gaubatz Stefan | Schartl Manfred
EGFR/Met association regulates EGFR TKI resistance in breast cancer

Author(s): Mueller Kelly | Yang Zeng-Quan | Haddad Ramsi | Ethier Stephen | Boerner Julie
Detection of Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Tumor Specimens from Various Ways by Denaturing High-performance Liquid Chromatography

Author(s): Siyuan CHEN | Zhihong CHEN | Ailin GUO | Jian SU | Ying HUANG | Shiliang CHEN | Xuchao ZHANG | Xuening YANG | Jinji YANG | Yilong WU
Genome profiling of ERBB2-amplified breast cancers

Author(s): Sircoulomb Fabrice | Bekhouche Ismahane | Finetti Pascal | Adélaïde José | Hamida Azza | Bonansea Julien | Raynaud Stéphane | Innocenti Charlène | Charafe-Jauffret Emmanuelle | Tarpin Carole | Ayed Farhat | Viens Patrice | Jacquemier Jocelyne | Bertucci François | Birnbaum Daniel | Chaffanet Max
Chromogenic in situ hybridization to detect EGFR gene copy number in cell blocks from fine-needle aspirates of non small cell lung carcinomas and lung metastases from colo-rectal cancer

Author(s): Simone Giovanni | Mangia Anita | Malfettone Andrea | Rubini Vincenza | Siciliano Michele | Di Benedetto Anna | Terrenato Irene | Novelli Flavia | Mottolese Marcella
Treatment of Brain Metastasis from Lung Cancer

Author(s): Alexander Chi | Ritsuko Komaki
Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice

Author(s): Laura P. Stabile | Mary E. Rothstein | Phouthone Keohavong | Diana Lenzner | Stephanie R. Land | Autumn L. Gaither-Davis | K. Jin Kim | Naftali Kaminski | Jill M. Siegfried
Panitumumab: the evidence for its use in the treatment of metastatic colorectal cancer

Author(s): Rossana Berardi | Azzurra Onofri | Mirco Pistelli | et al
First-line targeted therapies in the treatment of metastatic colorectal cancer – role of cetuximab

Author(s): Giuseppe Tonini | Alice Calvieri | Bruno Vincenzi | Daniele Santini
Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer

Author(s): Peraldo-Neia Caterina | Migliardi Giorgia | Mello-Grand Maurizia | Montemurro Filippo | Segir Raffaella | Pignochino Ymera | Cavalloni Giuliana | Torchio Bruno | Mosso Luciano | Chiorino Giovanna | Aglietta Massimo
Renal function during rofecoxib therapy in patients with metastatic cancer: retrospective analysis of a prospective phase II trial

Author(s): Reinhold Stephan | Reichle Albrecht | Leiminger Sonja | Bergler Tobias | Hoffmann Ute | Krüger Bernd | Banas Bernhard | Krämer Bernhard
Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas

Author(s): Pignochino Ymera | Sarotto Ivana | Peraldo-Neia Caterina | Penachioni Junia | Cavalloni Giuliana | Migliardi Giorgia | Casorzo Laura | Chiorino Giovanna | Risio Mauro | Bardelli Alberto | Aglietta Massimo | Leone Francesco
Liver cancer: Targeted future options

Author(s): Andreas Pircher | Michael Medinger | Joachim Dr
Epidermal Growth Factor Receptor in Pancreatic Cancer

Author(s): Melissa Oliveira-Cunha | William G. Newman | Ajith K. Siriwardena
Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers

Author(s): Marie-Pierre Buisine, Agnès Wacrenier, Christophe Mariette, Emmanuelle Leteurtre, Fabienne Escande, Sana Aissi, Amandine Ketele, Annette Leclercq, Nicole Porchet, Thécla Lesuffleur
Renal outcome in adults with renal insufficiency and irregular asymmetric kidneys

Author(s): Neild Guy | Thomson Gill | Nitsch Dorothea | Woolfson Robin | Connolly John | Woodhouse Christopher
Acquired Resistance of Lung Adenocarcinomas to Gefitinib or Erlotinib Is Associated with a Second Mutation in the EGFR Kinase Domain

Author(s): Pao William | Miller Vincent A | Politi Katerina A | Riely Gregory J | Somwar Romel | Zakowski Maureen F | Kris Mark G | Varmus Harold
Glioblastoma multiforme with long term survival

Author(s): Deb Prabal | Sharma Mehar | Mahapatra Ashok | Agarwal Deepak | Sarkar Chitra
Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer

Author(s): O'Grady Michael | Raha Debasish | Hanson Bonnie | Bunting Michaeline | Hanson George
Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors

Author(s): Balko Justin | Potti Anil | Saunders Christopher | Stromberg Arnold | Haura Eric | Black Esther
A novel mutation in the tyrosine kinase domain of ERBB2 in hepatocellular carcinoma

Author(s): Bekaii-Saab Tanios | Williams Nita | Plass Christoph | Calero Miguel | Eng Charis
Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells

Author(s): Ando Seijitsu | Otani Hitomi | Yagi Yasuhiro | Kawai Kenzo | Araki Hiromasa | Fukuhara Shirou | Inagaki Chiyoko
Fatal interstitial lung disease associated with oral erlotinib therapy for lung cancer

Author(s): Makris Demosthenes | Scherpereel Arnaud | Copin Marie | Colin Guillaume | Brun Luc | Lafitte Jean | Marquette Charles
EGFR associated expression profiles vary with breast tumor subtype

Author(s): Hoadley Katherine | Weigman Victor | Fan Cheng | Sawyer Lynda | He Xiaping | Troester Melissa | Sartor Carolyn | Rieger-House Thais | Bernard Philip | Carey Lisa | Perou Charles
Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain

Author(s): de Gunst Matheus | Gallegos-Ruiz Marielle | Giaccone Giuseppe | Rodriguez Jose
PAI-1 is a Critical Upstream Regulator of the TGF-β1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma

Author(s): Cynthia E. Wilkins-Port | Craig E. Higgins | Jennifer Freytag | Stephen P. Higgins | J. Andrew Carlson | Paul J. Higgins
Epidermal growth factor receptor structural alterations in gastric cancer

Author(s): Moutinho Cátia | Mateus Ana | Milanezi Fernanda | Carneiro Fátima | Seruca Raquel | Suriano Gianpaolo
The Relationship between EGFR Mutations and Response and Prognosis of Tyrosine Kinase Inhibitors in Advanced Non-small-cell Lung Cancer

Author(s): Xinyong ZHANG | Liyan XU | Hui WANG | Yunzhong ZHU | Zhe LIU | Wentao YUE | Junfang TANG | Wei WU | Zan LIU | Yuhua WU | Chunyan ZHANG | Yuankai SHI | Mengzhao WANG | Heling SHI | Mingzhi LI | Qiyi MENG | Lili GUO | Jinghui WANG | Xuebing LI
High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies

Author(s): Do Hongdo | Krypuy Michael | Mitchell Paul | Fox Stephen | Dobrovic Alexander
Phosphatidylinositol 3-Kinase and NF-kappaB Involved in Epidermal Growth Factor-Induced Matrix Metalloproteinase-9 Expression

Author(s): Shuvojit Moulik | Triparna Sen | Anindita Dutta | Aniruddha Banerji | Chinmoy Ghosh | Shamik Das | Amitava Chatterjee
Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell lines

Author(s): Solmi Rossella | Lauriola Mattia | Francesconi Mirko | Martini Désirée | Voltattorni Manuela | Ceccarelli Claudio | Ugolini Giampaolo | Rosati Giancarlo | Zanotti Simone | Montroni Isacco | Mattei Gabriella | Taffurelli Mario | Santini Donatella | Pezzetti Furio | Ruggeri Alessandro | Castellani Gastone | Guidotti Lia | Coppola Domenico | Strippoli Pierluigi
EGFR as a therapeutic target in glioblastoma

Author(s): David M Siebert | Sophia F Shakur | Peter Pytel | Lukas Rimas
Tyrosine kinase domain gene polymorphism of epidermal growth factor receptor in gastric cancer in northern Iran

Author(s): Jeivad F | Abediankenari S | Shokrzadeh M | Ghasemi M | Taghvaei T | Ansari Z | Najafi Fard M | Hassannia H | Sayiari Mazandarani M | Biranvand E
The Effects of Artesunate on the Expression of EGFR and ABCG2 in A549 Human Lung Cancer Cells and a Xenograft Model

Author(s): Hu Ma | Quan Yao | An-Mei Zhang | Sheng Lin | Xin-Xin Wang | Lei Wu | Jian-Guo Sun | Zheng-Tang Chen
Ekspresja białek Id1, epidermalnego czynnika wzrostu (EGF) i jego receptora (EGF-R) w nowotworach złośliwych jajnika

Author(s): Artur Czekierdowski | Sylwia Czekierdowska | Jarosław Daniłoś | Andrzej Nowakowski | Norbert Stachowicz
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways

Author(s): Pickhard Anja | Margraf Johanna | Knopf Andreas | Stark Thomas | Piontek Guido | Beck Carolin | Boulesteix Anne-Laure | Scherer Elias | Pigorsch Steffi | Schlegel Jürgen | Arnold Wolfgang | Reiter Rudolf
Clinical pharmacogenomic testing of KRAS, BRAF and EGFR mutations by high resolution melting analysis and ultra-deep pyrosequencing

Author(s): Borràs Emma | Jurado Ismael | Hernan Imma | Gamundi María | Dias Miguel | Martí Isabel | Mañé Begoña | Arcusa Àngels | Agúndez José | Blanca Miguel | Carballo Miguel
Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation

Author(s): Jiao Yisheng | Ou Wenbin | Meng Fanguo | Zhou Haimeng | Wang Aiyuan
Stromal micropapillary pattern predominant lung adenocarcinoma - a report of two cases

Author(s): Ohe Miki | Yokose Tomoyuki | Sakuma Yuji | Osanai Sachie | Hasegawa Chikako | Washimi Kota | Nawa Kimitoshi | Woo Tetsukan | Hamanaka Rurika | Nakayama Haruhiko | Kameda Yoichi | Yamada Kouzo | Isobe Takeshi
Afatinib treatment in advanced non-small cell lung cancer

Author(s): Hurwitz JL | Scullin P | Campbell L
Molecular Genetics and Gene Therapy in Esophageal Cancer: a Review Article

Author(s): Mohammad Reza Noori Daloii Ph.D. | Radin Maheronnaghsh | Mohammad Kazem Sayyah
Role of EGFR Mutation Status in Patients with Stage III Non-squamous Non-small Cell Lung Cancer Treated with Chemoradiotherapy

Author(s): Fuhai LI | Hua BAI | Xia’nan LI | Meina WU | Rong YU | Anhui SHI | Li YIN | Jie WANG | Guangying ZHU
Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease

Author(s): Kawase Shigeo | Hattori Noboru | Ishikawa Nobuhisa | Horimasu Yasushi | Fujitaka Kazunori | Furonaka Osamu | Isobe Takeshi | Miyoshi Seigo | Hamada Hironobu | Yamane Takashi | Yokoyama Akihito | Kohno Nobuoki
The Role of EGFR Inhibitors in the Treatment of Metastatic Anal Canal Carcinoma: A Case Series

Author(s): Muhammad W. Saif | Ewa Kontny | Kostas N. Syrigos | Armin Shahrokni
Modified Restriction Enzyme-based Detection of EGFR Mutations in Lung Cancer

Author(s): Fan YANG | Kezhong CHEN | Guanchao JIANG | Jianfeng LI | Jun WANG
Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

Author(s): Centeno Irene | Blay Pilar | Santamaría Iñigo | Astudillo Aurora | Pitiot Ana | Osorio Fernando | González-Arriaga Patricia | Iglesias Fernando | Menéndez Primitiva | Tardón Adonina | Freije Jose | Balbín Milagros
In silico studies on marine actinomycetes as potential inhibitors for Glioblastoma multiforme

Author(s): Palani Kirubakaran | Roopa Kothapalli | Kh. Dhanachandra Singh | Selvaraman Nagamani | Subramanian Arjunan | Karthikeyan Muthusamy
Structure-based drug design and AutoDock study of potential protein tyrosine kinase inhibitors

Author(s): Hamed Ismail Ali | Tomofumi Nagamatsu | Eiichi Akaho
Model based design of inhibitors for c-jun

Author(s): Pallavi Chauhan 1 | Madhvi Shakya
Tumor Resistance to Molecularly Targeted Agents

Author(s): James Chen | Peter S. Edelstein | Philip J. Johnson | Robert Lustig | Lucien Ooi
HER2 splice variants and their relevance in breast cancer

Author(s): Marianna Sasso | Francesca Bianchi | Valentina Ciravolo | Elda Tagliabue | Manuela Campiglio
Study on Point Mutations of K-ras Gene in Non-small Cell Lung Cancer in Guangxi

Author(s): Weixiang ZHONG | Mingwu CHEN | Lei XIAN | Manhong LI
Higher Serum Potassium Level Associated with Late Stage Chronic Kidney Disease

Author(s): Ming-Fang Hsieh | I-Wen Wu | Chin-Chan Lee | Shun-Yin Wang | Mai-Szu Wu
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