Search Articles for "GPCR"

Scaffolding proteins in G-protein signaling

Author(s): Andreeva Alexandra | Kutuzov Mikhail | Voyno-Yasenetskaya Tatyana

Fungal GPCR signaling in pheromone response

Author(s): Kothe E | Erdmann S | Knabe N | Jung E-M

Frequent substructure mining of GPCR ligands

Author(s): Horst E | Bender A | IJzerman AP

The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury

Protean Agonists: A looking glass for GPCR and G Protein function

Author(s): Mr Mahip Kalyan Verma | Dr. Anantha Naik Nagappa

Illuminating the life of GPCRs

Author(s): Böhme Ilka | Beck-Sickinger Annette

AKAR2-AKAP12 fusion protein "biosenses" dynamic phosphorylation and localization of a GPCR-based scaffold

Author(s): Tao Jiangchuan | Wang Hsien-yu | Malbon Craig

PDGF-induced cell motility depends on EDG-1

Author(s): Terry Peter

Signaling and regulation of G protein-coupled receptors in airway smooth muscle

Author(s): Billington Charlotte | Penn Raymond

Lower rate of genomic variation identified in the trans-membrane domain of monoamine sub-class of Human G-Protein Coupled Receptors: The Human GPCR-DB Database

Author(s): Wahlestedt Claes | Brookes Anthony | Mottagui-Tabar Salim

Chemical genetics reveals an RGS/G-protein role in the action of a compound.

On the origins of arrestin and rhodopsin

Author(s): Alvarez Carlos

The amphioxus (Branchiostoma floridae) genome contains a highly diversified set of G protein-coupled receptors

Author(s): Nordström Karl | Fredriksson Robert | Schiöth Helgi

Development of new in silico methods to identify ligands for orphan GPCR

Author(s): Weill Nathanael | Rognan Didier

Homology modeling and docking studies of human G-Protein coupled receptor involved in taste perception

Author(s): Padmavathi G. V. | Nataraj Sekhar P. | Kavi Kishor P. B. | Vishal Kumar Shah A. | Saralakumari D.

GPCRTree: online hierarchical classification of GPCR function

Endothelin-1, an Endogenous Irreversible Agonist in Search of an Allosteric Inhibitor

Author(s): Jo G.R. De Mey | Matthijs G. Compeer | Merlijn J. Meens

Exploratory Studies on Development of the Chemokine Receptor CXCR4 Antagonists Toward Downsizing

Author(s): Hirokazu Tamamura | Hiroshi Tsutsumi | Wataru Nomura | Nobutaka Fujii

GPCR Conformations: Implications for Rational Drug Design

Author(s): Abby L. Parrill | Debra L. Bautista

Original Fluorescent Ligand-Based Assays Open New Perspectives in G-Protein Coupled Receptor Drug Screening

Expanding the Concept of G Protein-Coupled Receptor (GPCR) Dimer Asymmetry towards GPCR-Interacting Proteins

Author(s): Maud Kamal | Pascal Maurice | Ralf Jockers

Cross-talk between Bradykinin and Epidermal Growth Factor in Regulating IL-6 Production in Human Airway Smooth Muscle Cells

Author(s): Po-Hao Feng | Te-Chih Hsiung | Han-Pin Kuo | Chien-Da Huang

A cell spot microarray method for production of high density siRNA transfection microarrays

Virtual screening of GPCRs: An in silico chemogenomics approach

Author(s): Jacob Laurent | Hoffmann Brice | Stoven Véronique | Vert Jean-Philippe

Delayed internalization and lack of recycling in a beta2-adrenergic receptor fused to the G protein alpha-subunit

The information highways of a biotechnological workhorse – signal transduction in Hypocrea jecorina

Author(s): Schmoll Monika

Analysis of the goldfish Carassius auratus olfactory epithelium transcriptome reveals the presence of numerous non-olfactory GPCR and putative receptors for progestin pheromones

Author(s): Kolmakov Nikolay | Kube Michael | Reinhardt Richard | Canario Adelino

Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates

Author(s): Klutz Athena | Gao Zhan-Guo | Lloyd John | Shainberg Asher | Jacobson Kenneth

Cell signaling and transcription factor genes expressed during whole body regeneration in a colonial chordate

Author(s): Rinkevich Yuval | Rinkevich Baruch | Reshef Ram

G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential signaling to MAPK and GPCR recycling

Author(s): Tao Jiangchuan | Malbon Craig

The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents

Author(s): Haitina Tatjana | Fredriksson Robert | Foord Steven | Schiöth Helgi | Gloriam David

Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M1 vs M2 muscarinic acetylcholine receptors

Author(s): Mosser Valerie | Jones Kymry | Hoffman Katie | McCarty Nael | Jackson Darrell

Evolution of the class C GPCR Venus flytrap modules involved positive selected functional divergence

The repertoire of G-protein-coupled receptors in Xenopus tropicalis

Author(s): Ji Yanping | Zhang Zhen | Hu Yinghe

Differences in duplication age distributions between human GPCRs and their downstream genes from a network prospective

Author(s): Huang Yong | Zheng Ying | Su Zhixi | Gu Xun

Luciferase activity under direct ligand-dependent control of a muscarinic acetylcholine receptor

Author(s): Thor Doreen | Le Duc Diana | Strotmann Rainer | Schöneberg Torsten

Gene Expression and Serum Cytokine Profiling of Low Stage CLL Identify WNT/PCP, Flt-3L/Flt-3 and CXCL9/CXCR3 as Regulators of Cell Proliferation, Survival and Migration

7TMRmine: a Web server for hierarchical mining of 7TMR proteins

Author(s): Lu Guoqing | Wang Zhifang | Jones Alan | Moriyama Etsuko

Expression and function of proton-sensing G-protein-coupled receptors in inflammatory pain

Author(s): Chen Ying-Ju | Huang Chia-Wei | Lin Chih-Shin | Chang Wen-Han | Sun Wei-Hsin

Production and characterisation of monoclonal antibodies against RAI3 and its expression in human breast cancer

Prolonged somatostatin therapy may cause down–regulation of SSTR–like GPCRs on Schistosoma mansoni

Dynamic imaging of cannabinoid receptor 1 vesicular trafficking in cultured astrocytes

Author(s): Kyle D Osborne | William Lee | Erik B Malarkey | Andrew J Irving | Vladimir Parpura

Differential requirement of the epidermal growth factor receptor for G protein-mediated activation of transcription factors by lysophosphatidic acid

Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach

Author(s): Parravicini Chiara | Abbracchio Maria | Fantucci Piercarlo | Ranghino Graziella

Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists

The serendipitous origin of chordate secretin peptide family members

Author(s): Cardoso João | Vieira Florbela | Gomes Ana | Power Deborah

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

Classification of G-protein coupled receptors based on support vector machine with maximum relevance minimum redundancy and genetic algorithm

Author(s): Li Zhanchao | Zhou Xuan | Dai Zong | Zou Xiaoyong

A novel chemogenomics analysis of G protein-coupled receptors (GPCRs) and their ligands: a potential strategy for receptor de-orphanization

A novel alternatively spliced isoform of the mu-opioid receptor: functional antagonism

Role of the G Protein-Coupled Receptor, mGlu1, in Melanoma Development

Author(s): Janet Wangari-Talbot | James Goydos | Suzie Chen

Incidence of Childhood Cancers in Golestan Province of Iran

Protein Based Drug Discovery

Role of ionotropic GABA, glutamate and glycine receptors in the tonic and reflex control of cardiac vagal outflow in the rat

Author(s): Hildreth Cara | Goodchild Ann

Ligand competition assays indicate allosterism and insufficiency of the ternary complex model

Author(s): Eyad Qunaibi | Roger Barber

Differential expression of Gs in a murine model of homocysteinemic heart failure

Dominant negative effect of the extracellular domain of CASR

Author(s): Min Pi | Junhui Chen | Wenyu Zhu | et al

GPCRs Revisited: New Insights Lead to Novel Drugs

Author(s): Richard M. Eglen | Terry Reisine

Dual-Color Bioluminescence Analysis for Quantitatively Monitoring G-Protein-Coupled Receptor and β-Arrestin Interactions

Author(s): A.K.M. Kafi | Mitsuru Hattori | Naomi Misawa | Takeaki Ozawa

CARMA3: A novel scaffold protein in regulation of NF-κB activation and diseases

Author(s): Jiyuan Sun

Impaired desensitization of a human polymorphic α2B-adrenergic receptor variant enhances its sympatho-inhibitory activity in chromaffin cells

Author(s): Nguyen Kristy | Kassimatis Theodoros | Lymperopoulos Anastasios

The formyl peptide receptor like-1 and scavenger receptor MARCO are involved in glial cell activation in bacterial meningitis

The G protein-coupled receptors in the pufferfish Takifugu rubripes

Author(s): Sarkar Anita | Kumar Sonu | Sundar Durai

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

Author(s): Atwood Brady | Lopez Jacqueline | Wager-Miller James | Mackie Ken | Straiker Alex

Soft X-ray Laser Microscopy of Lipid Rafts towards GPCR-Based Drug Discovery Using Time-Resolved FRET Spectroscopy

Functional Consequences of GPCR Heterodimerization: GPCRs as Allosteric Modulators

Author(s): Karla K.V. Haack | Nael A. McCarty

Molecular Approaches To Target GPCRs in Cancer Therapy

Functional and Structural Overview of G-Protein-Coupled Receptors Comprehensively Obtained from Genome Sequences

Author(s): Makiko Suwa | Minoru Sugihara | Yukiteru Ono

Mutações do Gene do Receptor Sensível ao Cálcio Extracelular e Suas Doenças Associadas

Author(s): Miyashiro Kozue | Hauache Omar M.

Using green fluorescent protein to understand the mechanisms of G-protein-coupled receptor regulation

Author(s): Ferguson S.S.G.

Insulin signaling inhibits the 5-HT2C receptor in choroid plexus via MAP kinase

Cytochalasin B triggers a novel pertussis toxin sensitive pathway in TNF-alpha primed neutrophils

A database for G proteins and their interaction with GPCRs

Author(s): Elefsinioti Antigoni | Bagos Pantelis | Spyropoulos Ioannis | Hamodrakas Stavros

Identification of functional SNPs in the 5-prime flanking sequences of human genes

Tre1, a G Protein-Coupled Receptor, Directs Transepithelial Migration of Drosophila Germ Cells

Author(s): Kunwar Prabhat S | Starz-Gaiano Michelle | Bainton Roland J | Heberlein Ulrike | Lehmann Ruth

Effect of Thyrotropin Releasing Hormone (TRH) on Gene Expressions in Rat Pancreas: Approach by Microarray Hybridization

Author(s): Yano N | Luo LG

A method for the prediction of GPCRs coupling specificity to G-proteins using refined profile Hidden Markov Models

Author(s): Sgourakis Nikolaos | Bagos Pantelis | Papasaikas Panagiotis | Hamodrakas Stavros

S-Nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner

Author(s): Kokkola Tarja | Savinainen Juha | Mönkkönen Kati | Retamal Montse | Laitinen Jarmo

Genome wide survey of G protein-coupled receptors in Tetraodon nigroviridis

Author(s): Metpally Raghu | Sowdhamini Ramanathan

A strategy using NMR peptide structures of thromboxane A2 receptor as templates to construct ligand-recognition pocket of prostacyclin receptor

Author(s): Ruan Cheng-Huai | Wu Jaixin | Ruan Ke-He

Human Latrophilin-2 is Expressed in the Cytotrophoblast and Syncytiotrophoblast of Placenta and in Endothelial Cells

Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligands

RINGdb: An integrated database for G protein-coupled receptors and regulators of G protein signaling

Evolution of secretin family GPCR members in the metazoa

Author(s): Cardoso João | Pinto Vanda | Vieira Florbela | Clark Melody | Power Deborah

Exploring developmental, functional, and evolutionary aspects of amphioxus sensory cells

Author(s): Gouki Satoh

GrlJ, a Dictyostelium GABAB-like receptor with roles in post-aggregation development

Author(s): Prabhu Yogikala | Müller Rolf | Anjard Christophe | Noegel Angelika

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

R7-binding protein targets the G protein β5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain

The G protein-coupled receptor subset of the rat genome

Author(s): Gloriam David | Fredriksson Robert | Schiöth Helgi

The effect of deletion of the orphan G – protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice

Modelling the structures of G protein-coupled receptors aided by three-dimensional validation

Author(s): Dastmalchi Siavoush | Church W Bret | Morris Michael

Receptor downregulation and desensitization enhance the information processing ability of signalling receptors

Author(s): Shankaran Harish | Wiley H Steven | Resat Haluk

Receptor-Drug Interaction: Europium Employment for Studying the Biochemical Pathway of G-Protein-Coupled Receptor Activation

Author(s): Colabufo Nicola Antonio | Perrone Maria Grazia | Contino Marialessandra | Berardi Francesco | Perrone Roberto

Phylogenomic Analysis Reveals Extensive Phylogenetic Mosaicism in the Human GPCR Superfamily

Author(s): Robin G. Allaby | Mathew Woodwark

The repertoire of G protein-coupled receptors in the sea squirt Ciona intestinalis

Author(s): Kamesh N | Aradhyam Gopala | Manoj Narayanan

Expression analysis of G Protein-Coupled Receptors in mouse macrophages

Expression profile of the entire family of Adhesion G protein-coupled receptors in mouse and rat

Dissection of Functional Residues in Receptor Activity-Modifying Proteins Through Phylogenetic and Statistical Analyses

Author(s): Alfonso Benítez-Páez | Sonia Cárdenas-Brito

Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells

Author(s): Baker Jillian

A formylpeptide receptor, FPRL1, acts as an efficient coreceptor for primary isolates of human immunodeficiency virus

GPR17: Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors

Author(s): Parravicini Chiara | Ranghino Graziella | Abbracchio Maria | Fantucci Piercarlo

Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium

Galphas-coupled receptor signaling actively down-regulates α4β1-integrin affinity: A possible mechanism for cell de-adhesion

Author(s): Chigaev Alexandre | Waller Anna | Amit Or | Sklar Larry

GRK5 deficiency exaggerates inflammatory changes in TgAPPsw mice

Author(s): Li Longxuan | Liu Jun | Suo William

The GHS-R Blocker D-[Lys3] GHRP-6 Serves as CCR5 Chemokine Receptor Antagonist

Author(s): Kalpesh Patel, Vishwa Deep Dixit, Jun Ho Lee, Jie Wan Kim, Eric M. Schaffer, Dzung Nguyen, Dennis D. Taub

A Cholesterol and Actinide Dependent Shadow Biosphere of Archaea And Viroids in Metabolic Syndrome X

Author(s): Ravikumar Kurup A. | Parameswara Achutha Kurup

Incidence of Childhood Cancers in Golestan Province of Iran

Docking of human rhodopsin mutant (Gly90àAsp) with beta-arrestin and cyanidin 3-rutinoside to cure night blindness

Author(s): Shagufta Kanwal | Sumaira Nishat | Muhammad Irfan Khan

Designing allosteric modulators for active conformational state of m-glutamate G-protein coupled receptors

Author(s): Ankur Omer | CVS Siva Prasad

G-protein Coupled Receptor Dimerization

Author(s): Nikzad Nikbin | Christine Edwards | Christopher A Reynolds

Molecular evolution of a chordate specific family of G protein-coupled receptors

Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets

Integrating GPCR-specific information with full text articles

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

TM-MOTIF: an alignment viewer to annotate predicted transmembrane helices and conserved motifs in aligned set of sequences

Modeling of the hEP1 receptor based on the crystallographic structure of β2-adrenergic receptor and its assessment with docking studies and molecular dynamics simulation

Author(s): B Zare | A Madadkar-Sobhani | S Dastmalchi | M Mahmoudian

Mutation of the histidin residue of the DRH motif in vasopressin V2 receptor expression and function

Author(s): H Mir Mohammad Sadeghi | M Rabbani | A Jafarian | H Najafzadeh | L Safaeian

RFamide Peptides: Structure, Function, Mechanisms and Pharmaceutical Potential

Author(s): Maria Findeisen | Daniel Rathmann | Annette G. Beck-Sickinger

Large-scale RNAi screen of G protein-coupled receptors involved in larval growth, molting and metamorphosis in the red flour beetle

Author(s): Bai Hua | Zhu Fang | Shah Kapil | Palli Subba

In Silico Veritas: The Pitfalls and Challenges of Predicting GPCR-Ligand Interactions

Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR

Author(s): Frederic Delom | Delphine Fessart

Insights from the analysis of conserved motifs and permitted amino acid exchanges in the human, the fly and the worm GPCR clusters

Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2

Differential regulation of diacylglycerol kinase isoform in human failing hearts

Genome-wide profiling of G protein-coupled receptors in cerebellar granule neurons using high-throughput, real-time PCR

Author(s): Maurel Benjamin | Le Digarcher Anne | Dantec Christelle | Journot Laurent

GPCR-SSFE: A comprehensive database of G-protein-coupled receptor template predictions and homology models

Author(s): Worth Catherine | Kreuchwig Annika | Kleinau Gunnar | Krause Gerd

Cell-free synthesis of a functional G protein-coupled receptor complexed with nanometer scale bilayer discs

Author(s): Yang Jian-Ping | Cirico Tatiana | Katzen Federico | Peterson Todd | Kudlicki Wieslaw

Nitric oxide/cGMP pathway signaling actively down-regulates α4β1-integrin affinity: an unexpected mechanism for inducing cell de-adhesion

Author(s): Chigaev Alexandre | Smagley Yelena | Sklar Larry

Immunolocalization of the short neuropeptide F receptor in queen brains and ovaries of the red imported fire ant (Solenopsis invicta Buren)

Author(s): Lu Hsiao-Ling | Pietrantonio Patricia

A model for the evaluation of domain based classification of GPCR

Author(s): Tannu Kumari | Bhaskar Pant | Kamalraj R. Pardasani

REVIEW : Recent advances in developing web-servers for predicting protein attributes

Author(s): Kuo-Chen Chou | Hong-Bin Shen

Epidermal Growth Factor Receptor (EGFR) Crosstalks in Liver Cancer

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