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Inhibitors of the Hepatitis C Virus RNA-Dependent RNA Polymerase NS5B

Author(s): Megan H. Powdrill | Jean A. Bernatchez | Matthias Götte
Nano-vectors for efficient liver specific gene transfer

Author(s): Atul Pathak | Suresh P Vyas | Kailash C Gupta
Novel topical therapies for distal colitis

Author(s): Ian Craig Lawrance
Notch signaling in glioblastoma: a developmental drug target?

Author(s): Lino Maria | Merlo Adrian | Boulay Jean-Louis
Targeting metastatic upper gastrointestinal adenocarcinomas

Author(s): Jennifer L Spratlin, Quincy Chu, Sheryl Koski, Karen King, Karen Mulder
Molecular Docking of Aromatase Inhibitors

Author(s): Naravut Suvannang | Chanin Nantasenamat | Chartchalerm Isarankura-Na-Ayudhya | Virapong Prachayasittikul
Synthesis and Antimalarial Activity of Novel Dihydro-Artemisinin Derivatives

Author(s): Yang Liu | Kunqiang Cui | Weiqiang Lu | Wei Luo | Jian Wang | Jin Huang | Chun Guo
Novel molecular imaging platform for monitoring oncological kinases

Author(s): Nyati Shyam | Ross Brian | Rehemtulla Alnawaz | Bhojani Mahaveer
Viable mouse gene ablations that robustly alter brain Aβ levels are rare

Author(s): Toyn Jeremy | Lin Xu-Alan | Thompson Mark | Guss Valerie | Meredith Jere | Sankaranarayanan Sethu | Barrezueta Nestor | Corradi John | Majumdar Antara | Small Daniel | Hansard Melissa | Lanthorn Thomas | Westphal Ryan | Albright Charles
A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening

Author(s): An Steven | Askovich Peter | Zarembinski Thomas | Ahn Kwangmi | Peltier John | von Rechenberg Moritz | Sahasrabudhe Sudhir | Fredberg Jeffrey
Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives

Author(s): Tseng Chih-Yuan | Mane Jonathan | Winter Philip | Johnson Lorelei | Huzil Torin | Izbicka Elzbieta | Luduena Richard | Tuszynski Jack
Bone marrow stromal cells from multiple myeloma patients uniquely induce bortezomib resistant NF-κB activity in myeloma cells

Author(s): Markovina Stephanie | Callander Natalie | O'Connor Shelby | Xu Guangwu | Shi Yufang | Leith Catherine | Kim KyungMann | Trivedi Parul | Kim Jaehyup | Hematti Peiman | Miyamoto Shigeki
Hepatitis C Virus NS3/4A Protease Inhibitors: A Light at the End of the Tunnel

Author(s): Laurent Chatel-Chaix | Martin Baril | Daniel Lamarre
BP1, an Isoform of DLX4 Homeoprotein, Negatively Regulates BRCA1 in Sporadic Breast Cancer

Author(s): Brian J. Kluk, Yebo Fu, Trina A. Formolo, Lei Zhang, Anne K. Hindle, Yan-gao Man, Robert S. Siegel, Patricia E. Berg, Chuxia Deng, Timothy A. McCaffrey, Sidney W. Fu
Protein Based Drug Discovery

Author(s): Joshi B. | Gupta G. | Gupta N. | Gupta M. | Trivedi S. | Patil P. | Jhadav A. | Vamsi K.K. | Khairnar Y. | Boraste A. | Mujapara A.
Insilco binding analysis of MKP-1 inhibitors

Author(s): Sukesh K. | Lavanya C. | Balavinayagamani G.
Novel technologies: A weapon against tuberculosis

Author(s): Vedha Hari B | Chitra Karuna | Bhimavarapu Ramadevi | Karunakaran Prabhu | Muthukrishnan N | Rani B
Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes

Author(s): Johnston Kelly | Wu Bo | Guimarães Ana | Ford Louise | Slatko Barton | Taylor Mark
Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer

Author(s): Zajac Magdalena | Gomez Gonzalo | Benitez Javier | Martínez-Delgado Beatriz
Development of PEGylated PLGA nanoparticle for controlled and sustained drug delivery in cystic fibrosis

Author(s): Vij Neeraj | Min Taehong | Marasigan Rhul | Belcher Christopher | Mazur Steven | Ding Hong | Yong Ken-Tye | Roy Indrajit
A widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins

Author(s): Pawłowski Krzysztof | Muszewska Anna | Lenart Anna | Szczepińska Teresa | Godzik Adam | Grynberg Marcin
Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C

Author(s): Murakami Yoshiki | Tanaka Masami | Toyoda Hidenori | Hayashi Katsuyuki | Kuroda Masahiko | Tajima Atsushi | Shimotohno Kunitada
The Novel Therapeutic Approaches of Breast Cancer Treatment by Inhibition of DNA Damage Signaling Pathways in erbb2 Gene

Author(s): Venkatesan Suba | Ravichandiran V | Arun Kumar Kuna, | Ranga Mahendranath
Survivin-T34A: molecular mechanism and therapeutic potential

Author(s): Jonathan R Aspe | Nathan R Wall
New advances in the treatment of gout: review of pegloticase

Author(s): Mattheus K Reinders | Tim L Th A Jansen
Pegylated liposomal doxorubicin in the management of ovarian cancer

Author(s): Gabriella Ferrandina | Giacomo Corrado | Angelo Licameli | et al
Development and targeted use of nilotinib in chronic myeloid leukemia

Author(s): Carmen Fava | Hagop Kantarjian | Jorge Cortes | Elias Jabbour
Topical retapamulin in the management of infected traumatic skin lesions

Author(s): Ribhi Shawar | Nicole Scangarella-Oman | MaryBeth Dalessandro | John Breton | Monique Twynholm | et al
GPCRs Revisited: New Insights Lead to Novel Drugs

Author(s): Richard M. Eglen | Terry Reisine
Hsp90/Cdc37 Chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug Withaferin A

Author(s): Grover Abhinav | Shandilya Ashutosh | Agrawal Vibhuti | Pratik Piyush | Bhasme Divya | Bisaria Virendra | Sundar Durai
Identification of novel conserved functional motifs across most Influenza A viral strains

Author(s): ElHefnawi Mahmoud | AlAidi Osama | Mohamed Nafisa | Kamar Mona | El-Azab Iman | Zada Suher | Siam Rania
Comparative nucleic acid transfection efficacy in primary hepatocytes for gene silencing and functional studies

Author(s): Park Jae-Seung | Surendran Sneha | Kamendulis Lisa | Morral Núria
Novel Strategy to Fabricate PLA/Au Nanocomposites as an Efficient Drug Carrier for Human Leukemia Cells in Vitro

Author(s): Li Jingyuan | Chen Chen | Wang Xuemei | Gu Zhongze | Chen Baoan
Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen

Author(s): Cimica Velasco | Smith Melissa | Zhang Zhikai | Mathur Deepti | Mani Sridhar | Kalpana Ganjam
Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

Author(s): Beverley Isherwood | Paul Timpson | Ewan J McGhee | Kurt I Anderson | Marta Canel | Alan Serrels | Valerie G Brunton | Neil O Carragher
Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease

Author(s): Sara De Iudicibus, Raffaella Franca, Stefano Martelossi, Alessandro Ventura, Giuliana Decorti
Peptide inhibition of human cytomegalovirus infection

Author(s): Melnik Lilia | Garry Robert | Morris Cindy
Dose study of the multikinase inhibitor, LY2457546, in patients with relapsed acute myeloid leukemia to assess safety, pharmacokinetics, and pharmacodynamics

Author(s): Wacheck V | Lahn M | Dickinson G | Füreder W | Meyer R | Herndlhofer S | Füreder T | Dorfner G | Pillay S | André V | Burkholder TP | Akunda JK | Flye-Blakemore L | Van Bockstaele D | Schlenk RF | Sperr W | Valent P
Review: ETHOSOMES: A NOVEL DRUG CARRIER

Author(s): Hitesh Jain* | Jitendra Patel | Kruti Joshi | Parth Patel | U M Upadhyay
Folate-mediated targeted and intracellular delivery of paclitaxel using a novel deoxycholic acid-O-carboxymethylated chitosan–folic acid micelles

Author(s): Wang F | Chen Y | Zhang D | Zhang Q | Zheng D | Hao L | Liu Y | Duan C | Jia L | Liu G
Metabolic pathway analysis and molecular docking analysis for identification of putative drug targets in Toxoplasma gondii: novel approach

Author(s): Budhayash Gautam1 | Gurmit Singh | Gulshan Wadhwa | Rohit Farmer | Satendra Singh | Atul Kumar Singh | Prashant Ankur Jain | Pramod Kumar Yadav
Stimulus Controlled Drug Delivery via Ultrasound Drug Delivery

Author(s): Dinesh Mali*, Yadunath Joshi, Vaibhav Borole and Vilasrao Kadam
Evaluation of Potential Anti-Pathogenic and Anti-Retroviral Effects of a Proprietary Bioactive Silicate Alka-Vita™/Alka-V6™/Alkahydroxy™ (AVAH)

Author(s): D Townsend | L M White | C E Lester | R C DeLeon | I Cisneros | V Maitin | C R Richardson | D A Vattem
Phase 0 clinical trial- an overview

Author(s): Aanchal Satija
3D QSAR Pharmacophore Modeling, in Silico Screening, and Density Functional Theory (DFT) Approaches for Identification of Human Chymase Inhibitors

Author(s): Mahreen Arooj | Sundarapandian Thangapandian | Shalini John | Swan Hwang | Jong Keun Park | Keun Woo Lee
Ionic Channels as Targets for Drug Design: A Review on Computational Methods

Author(s): Gregorio Fernández-Ballester | Asia Fernández-Carvajal | José Manuel González-Ros | Antonio Ferrer-Montiel
Discovery of Potential M2 Channel Inhibitors Based on the Amantadine Scaffold via Virtual Screening and Pharmacophore Modeling

Author(s): Linh Tran | Sy Bing Choi | Belal O. Al-Najjar | Muhammad Yusuf | Habibah A. Wahab | Ly Le
Embedded nanomicro syringe on chip for molecular therapy

Author(s): Jalil MA | Suwanpayak N | Kulsirirat K | Suttirak S | Ali J | Yupapin PP
Molecular docking of glucosamine-6-phosphate synthase in Rhizopus oryzae

Author(s): Kamalika Banerjee | Utkarsh Gupta | Sanjay Gupta | Gulshan Wadhwa | Reema Gabrani | Sanjeev Kumar Sharma | Chakresh Kumar Jain
Characterization and targeting of phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in renal cell cancer

Author(s): Elfiky Aymen | Aziz Saadia | Conrad Patricia | Siddiqui Summar | Hackl Wolfgang | Maira Michel | Robert Camp | Kluger Harriet
Cytoplasmic p21 is a potential predictor for cisplatin sensitivity in ovarian cancer

Author(s): Xia Xi | Ma Quanfu | Li Xiao | Ji Teng | Chen Pingbo | Xu Hongbin | Li Kezhen | Fang Yong | Weng Danhui | Weng Yanjie | Liao Shujie | Han Zhiqiang | Liu Ronghua | Zhu Tao | Wang Shixuan | Xu Gang | Meng Li | Zhou Jianfeng | Ma Ding
A MCP1 fusokine with CCR2-specific tumoricidal activity

Author(s): Rafei Moutih | Deng Jiusheng | Boivin Marie-Noëlle | Williams Patrick | Matulis Shannon | Yuan Shala | Birman Elena | Forner Kathy | Yuan Liangping | Castellino Craig | Boise Lawrence | MacDonald Tobey | Galipeau Jacques
Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway

Author(s): Xu Weiru | Lin Hongsheng | Zhang Ying | Chen Xinyi | Hua Baojin | Hou Wei | Qi Xin | Pei Yingxia | Zhu Xiaoyun | Zhao Zhizheng | Yang Liangliang
In Silico Identification of Structure Requirement for Novel Thiazole and Oxazole Derivatives as Potent Fructose 1,6-Bisphosphatase Inhibitors

Author(s): Ming Hao | Xiaole Zhang | Hong Ren | Yan Li | Shuwei Zhang | Fang Luo | Mingjuan Ji | Guohui Li | Ling Yang
Oncolytic Activities of Host Defense Peptides

Author(s): Sammy Al-Benna | Yechiel Shai | Frank Jacobsen | Lars Steinstraesser
DOCKING STUDIES ON NOVEL HUMAN CARBONIC ANHYDRASE II

Author(s): M. Vinoth | G. Jhansi Rani | P. Anitha
Effect of ANGIPARSTM, a new herbal drug on diabetic foot ulcer: A phase 2 clinical study

Author(s): Masoompour SM | Bagheri MH | Borhani Haghighi A | Novitsky YA | Sadeghi B | Gharibdoust F | Larijani B | Ranjbar Omrani G
Use of proteasome inhibitors in anticancer therapy

Author(s): Sara M. Schmitt | Lillian Lu | Q. Ping Dou
A REVIEW ON CHITOSAN-BASED HYDROGLES FOR THE DRUG DELIVERY SYSTEM

Author(s): Murugesh Shivashankar | Badal Kumar mandal | Roshini Yerappagari | Venkatesan Praveen Kumar
Plasmodium falciparum spermidine synthase

Author(s): Anup V. Patwa, Amit G. Nerkar*, Sanjay D. Sawant
Chalcones induced inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum

Author(s): Hemandra Kumar Tiwari1, Sanidhya Upadhyay1, Raj Kumar Upadhyay1,*, Manmeet Rawat2 and Arun Sharma2
Depletion of drug-surviving glioma cells by a second phase treatment with low concentration of salinomycin

Author(s): Zahid M. Delwar | Dimitrios Avramidis | Åke Siden | Mabel Cruz | Juan Sebastian Yakisich
Bioinformatic Analysis of Leishmania donovani Long-Chain Fatty Acid-CoA Ligase as a Novel Drug Target

Author(s): Jaspreet Kaur | Rameshwar Tiwari | Arun Kumar | Neeloo Singh
Subacute toxicity of a new camptothecin anticancer agent CPT13 administered by intravenous injection to rats

Author(s): Li-Min Wanga,b, Qing-Yong Li a, Yuan-Gang Zua,*, Li-Yan Chena
Functional co-evolutionary study of glucosamine-6-phosphate synthase in mycoses causing fungi

Author(s): Kamalika Banerjee | Sanjay Gupta | Sanjeev Kumar Sharma | Utkarsh Gupta | Chakresh Kumar Jain*
Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension?

Author(s): Hennigs Jan | Keller Gunhild | Baumann Hans | Honecker Friedemann | Kluge Stefan | Bokemeyer Carsten | Brümmendorf Tim | Klose Hans
Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope

Author(s): Hesketh Andy | Hill Chris | Mokhtar Jehan | Novotna Gabriela | Tran Ngat | Bibb Mervyn | Hong Hee-Jeon
Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer

Author(s): Toyokawa Gouji | Masuda Ken | Daigo Yataro | Cho Hyun-Soo | Yoshimatsu Masanori | Takawa Masashi | Hayami Shinya | Maejima Kazuhiro | Chino Makoto | Field Helen | Neal David | Tsuchiya Eiju | Ponder Bruce | Maehara Yoshihiko | Nakamura Yusuke | Hamamoto Ryuji
The monoclonal antibody Zt/f2 targeting RON receptor tyrosine kinase as potential therapeutics against tumor growth-mediated by colon cancer cells

Author(s): Yao Hang-Ping | Zhou Yong-Qing | Ma Qi | Guin Sunny | Padhye Snehal | Zhang Rui-Wen | Wang Ming-Hai
Identification of membrane associated drug targets in Borrelia burgdorferi ZS7- subtractive genomics approach

Author(s): Shivkumar Madagi | Vijayakumari Mali Patil | Saremy Sadegh | Abhishek Kumar Singh | Bhavana Garwal | Atreyi Banerjee | Usha Talambedu | Biplab Bhattacharjee
Genome subtraction for novel target definition in Salmonella typhi

Author(s): Bhawna Rathi | Nidhi Trivedi | Aditya N. Sarangi
CanGeneBase (CGB) - a database on cancer related genes

Author(s): Gopal Ramesh Kumar | Thankaswamy Kosalai Subazini | Kalyanamoorthy Subha | Chinnasamy Perumal Rajadurai | Latha Prabakar
Identification of potential P. falciparum transketolase inhibitors: pharmacophore design, in silico screening and docking studies

Author(s): Shweta Joshi | Alok Ranjan Singh | Uzma Saqib | Prakash Chandra Misra | Mohammad Imran Siddiqi | Jitendra Kumar Saxena
Everolimus in kidney transplantation

Author(s): Cooper JE | Christians U | Wiseman AC
Synthesis and Cytotoxic Evaluation of Novel N-Methyl-4-phenoxypicolinamide Derivatives

Author(s): Wei Li | Xin Zhai | Lu Ding | Limin Sun | Xiaomei Chen | Ping Gong | Tiemin Sun
High-density lipoproteins: a novel therapeutic target for cardiovascular disease

Author(s): TS Mohamed Saleem | PV Sandhya Rani | K Gauthaman
New Generation Novel Drugs Designed For Type 2 Diabetes By Insilico Computational Methods which block IRS4

Author(s): Thanigaivelan 1 | Sampoornam Balakrishnan 2 | Karpagam Veerappan 3 | Rasappan Periannan 4 | Shila Samuel*5
Identification of potential apicoplast associated therapeutic targets in human and animal pathogen Toxoplasma gondii ME49

Author(s): Sadegh Saremy | Biplab Bhattacharjee* | Mahdi Eskandarian Boroujeni | Jhinuk Chatterjee | Viditi Mittal
REVIEW ON NIOSOMES AS NOVEL DRUG DELIVERY SYSTEM

Author(s): Kumar Abhinav1 | Pal Jogender Lal | Jaiswal Amit | Singh Vishwabhan
Inhibition of U6 snRNA Transcription by PTEN

Author(s): Stephanie Cabarcas | Kounosuke Watabe | Laura Schramm

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