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TGF-beta1 immunohistochemistry and promoter methylation in chronic renal failure rats treated with Uremic Clearance Granules.

Author(s): Xu-Hong Miao | Chun-Guo Wang | Bao-Quan Hu | Ai Li | Cheng-Bin Chen | Wen-Qin Song
Fas/FasL expression in colorectal cancer. An immunohistochemical study.

Author(s): Anna Pryczynicz | Katarzyna Guzińska-Ustymowicz | Andrzej Kemona
TLR receptors in laryngeal carcinoma - immunophenotypic, molecular and functional studies.

Author(s): Jan Sikora | Magdalena Frydrychowicz | Mariusz Kaczmarek | Bartosz Brzezicha | Iwona Mozer-Lisewska | Mirosław Szczepański | Jan Zeromski
New Strategies to Develop Novel Pain Therapies: Addressing Thermoreceptors from Different Points of View

Author(s): Asia Fernández-Carvajal | Gregorio Fernández-Ballester | Isabel Devesa | José Manuel González-Ros | Antonio Ferrer-Montiel
Impairment of inhibition of HSP70 by Helicobacter pylori in human epithelial MKN7 cell line

Author(s): Aneta Targosz | Agata Ptak-Belowska | Urszula Szczyrk | Gracjana Krzysiek-Mączka | Wiesław W. Pawlik | Tomasz Brzozowski
BITTER MELON: A BITTER BODY WITH A SWEET SOUL

Author(s): Trivedi Rashmi V | Wadher Kamlesh J | Taksande Jayashri B | Umekar Milind J
EXPLORING PATHOGENIC MECHANISMS IN ISCHEMIC CEREBRAL DEATH: A RAY OF HOPE FOR DESIGNING NEW THERAPEUTIC STRATEGIES FOR STROKE

Author(s): Deshmukh A. B. | Patel J. K. | Prajapati A. R. | Patel A. P. | Mishra B.
TRANSCUTANEOUS DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW

Author(s): Sandhu Premjeet | Kataria Sahil | Bilandi Ajay | Jain Sonam | Rathore Devashish
Biomarkers in the management of ulcerative colitis: a brief review

Author(s): Masoodi, Ibrahim | Tijjani, Bashir M. | Wani, Hamidullah | Hassan, Nadeem Syed | Khan, Arshad Bashir | Hussain, Shabnum
Harungana madagascariensis in acute and repeated acetaminophen hepatotoxic rats

Author(s): A A Adeneye | J A Olagunju | S O Elias | D O Olatunbosun | A O Mustafa | O I Adeshile | A O Ashaolu | T A Laoye | A O Bamigboye | A O Adeoye
High level of urokinase plasminogen activator contributes to cholangiocarcinoma invasion and metastasis

Author(s): Parichut Thummarati | Sitsom Wijitburaphat | Aruna Prasopthum | Apaporn Menakongka | Banchob Sripa | Rutaiwan Tohtong | Tuangporn Suthiphongchai
Embryonic hepatocyte transplantation for hepatic cirrhosis: Efficacy and mechanism of action

Author(s): Wen-Ting Bin | Li-Mei Ma | Qing Xu | Xiao-Lin Shi
Riboflavin alleviates cardiac failure in Type I diabetic cardiomyopathy

Author(s): Guoguang Wang | Wei Li | Xiaohua Lu | Xue Zhao
5-Fluorouracil-loaded poly(ε-caprolactone) nanoparticles combined with phage E gene therapy as a new strategy against colon cancer

Author(s): Ortiz R | Prados J | Melguizo C | Arias JL | Ruíz MA | Álvarez PJ | Caba O | Luque R | Segura A | Aránega A
RECENT ADVANCES IN NOVEL DRUG DELIVERY SYSTEMS

Author(s): Manivannan Rangasamy | Kugalur Ganesan Parthiban
PHARMACOLOGICAL EFFECTS OF SNAKE VENOM L- AMINO ACID OXIDASES

Author(s): Joseph Baby | Rajan Sheeja S | M.V Jeevitha | S.U Ajisha
Effects of the Cyclin-Dependent Kinase 10 (CDK10) on the Tamoxifen Sensitivity of Keloid Samples

Author(s): Ying Liu | Zhibo Xiao | Daping Yang | Lihong Ren | Guofeng Liu | Lin Yang
Regulation of Expression of CXC Chemokines in Cultured Hepatocytes

Author(s): GhH Hassanshahiraviz | AJ Dickson
Homology modeling, active site prediction, and targeting the anti hypertension activity through molecular docking on endothelin – B receptor domain

Author(s): Daddam Jayasimha Rayalu | Chandrabose Selvaraj | Nagapatla Udaya Kumar | Sanjeev Kumar Singh | Ramakrishan Ganeshan | Panthangi Seshapani
ACVR1, a Therapeutic Target of Fibrodysplasia Ossificans Progressiva, Is Negatively Regulated by miR-148a

Author(s): Hao Song | Qi Wang | Junge Wen | Shunai Liu | Xuesong Gao | Jun Cheng | Deli Zhang
S-layer proteins from lactobacilli as vaccine delivery systems

Author(s): Axel Hollmann1, Lucrecia Delfederico, Anderson Miyoshi, Edgardo Anibal Disalvo, Graciela De Antoni, Liliana Semorile, Vasco Azevedo
Anti-Melanogenic Property of Geoditin A in Murine B16 Melanoma Cells

Author(s): Florence W. K. Cheung | Jia Guo | Yick-Hin Ling | Chun-Tao Che | Wing-Keung Liu
Structure Based Antibody-Like Peptidomimetics

Author(s): Ramachandran Murali | Mark I. Greene
Characterization of Different Functionalized Lipidic Nanocapsules as Potential Drug Carriers

Author(s): Paola Sánchez-Moreno | Juan Luis Ortega-Vinuesa | Antonio Martín-Rodríguez | Houría Boulaiz | Juan Antonio Marchal-Corrales | José Manuel Peula-García
Receptor and Channel Heteromers as Pain Targets

Author(s): Kelly A. Berg | Amol M. Patwardhan | Armen N. Akopian
Primary Study for the Therapeutic Dose and Time Window of Picroside II in Treating Cerebral Ischemic Injury in Rats

Author(s): Haitao Pei | Xi Su | Li Zhao | Hongyun Li | Yunliang Guo | Menizeng Zhang | Hui Xin
Phage Display Approaches for the Isolation of Monoclonal Antibodies Against Dengue Virus Envelope Domain III from Human and Mouse Derived Libraries

Author(s): Nicole J. Moreland | Patricia Susanto | Elfin Lim | Moon Y. F. Tay | Ravikumar Rajamanonmani | Brendon J. Hanson | Subhash G. Vasudevan
S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells

Author(s): Dong Chen | Xue-Feng Zheng | Ze-You Yang | Dong-Xiao Liu | Guo-You Zhang | Xue-Long Jiao | Hui Zhao
Interleukin-8 associates with adhesion, migration, invasion and chemosensitivity of human gastric cancer cells

Author(s): Wen-Xia Kuai | Qiong Wang | Xiao-Zhong Yang | Yao Zhao | Ren Yu | Xiao-Jun Tang
BDMC33, A Curcumin Derivative Suppresses Inflammatory Responses in Macrophage-Like Cellular System: Role of Inhibition in NF-κB and MAPK Signaling Pathways

Author(s): Ka-Heng Lee | Yuh-Lit Chow | Vidyadaran Sharmili | Faridah Abas | Noorjahan Banu Mohamed Alitheen | Khozirah Shaari | Daud Ahmad Israf | Nordin Haji Lajis | Ahmad Syahida
Homology modeling of dihydroorotase in Plasmodium falciparum

Author(s): Rajesh Sharma*, Anupama Parate and Abhishek Tiwari
Acrodermatitis enteropathica — therapeutic problems. Case report Acrodermatitis enteropathica - trudności terapeutyczne. Studium przypadku

Author(s): Małgorzata Sokołowska | Anna Kacalak-Rzepka | Magdalena Kiedrowicz | Romuald Maleszka
Dynamic Structure-Based Pharmacophore Model Development: A New and Effective Addition in the Histone Deacetylase 8 (HDAC8) Inhibitor Discovery

Author(s): Sundarapandian Thangapandian | Shalini John | Yuno Lee | Songmi Kim | Keun Woo Lee
Effects of aerobic training on some inflammatory markers in patients with rheumatoid arthritis

Author(s): Akbar Azamian Jazi | Mohammad Faramarzi | Mansour Salesi | Yaser Jafari shapoorabadi
The role of adhesive molecules in endometrial cancer: part I

Author(s): Michał Wojciechowski | Tomasz Krawczyk | Janusz Śmigielski | Andrzej Malinowski
Neuropsychological and neurobiological markers of the preclinical stage of Alzheimer’s disease

Author(s): Helenice Charchat Fichman | Rosinda Martins Oliveira | Conceição Santos Fernandes
PUTATIVE DRUG TARGET IDENTIFICATION FOR CHLAMYDIA TRACHOMATIS: AN INSILICO PROTEOME ANALYSIS

Author(s): Praveena A. | R. Sindhuja | Anuradha V. | S.K.M. Habeeb
Ionic Channels as Targets for Drug Design: A Review on Computational Methods

Author(s): Gregorio Fernández-Ballester | Asia Fernández-Carvajal | José Manuel González-Ros | Antonio Ferrer-Montiel
RNA Aptamer Evolution: Two Decades of SELEction

Author(s): Guillermo Aquino-Jarquin | Julia D. Toscano-Garibay
A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a

Author(s): Adi Mehta | Leroy Shervington | Chinmay Munje | Amal Shervington
The role of adhesive molecules in endometrial cancer: part II

Author(s): Michał Wojciechowski | Tomasz Krawczyk | Janusz Śmigielski | Andrzej Malinowski
Selenium Supplementation Reduced Oxidative Stress in Diethylnitrosamine-induced Hepatocellular Carcinoma in Rats

Author(s): Jamaludin Mohamed | Wong Lik Wei | Nazratun Nafizah Akhtar Husin | Nasar Y. Alwahaibi | Siti Balkis Budin
Harpagophytum procumbens (Devil's Claw): A Possible Natural Anti-Inflammatory Agent (An Experimental Study)

Author(s): Mohamad Ibrahim Ahmed | Mohamad Ismael Afifi | Ibrahim Hamdy Younos
Hepato Protective and Antioxidant Role of Berberis tinctoria lesch Leaves on Paracetamol Induced Hepatic Damage in Rats

Author(s): Kanda Samy Murugesh | Veerendra Channabasappa Yeligar | Bhim Charan Maiti | Tapan Kumar Maity
Mitogen-Activated Protein Kinase Pathways Following Traumatic Brain Injury

Author(s): Naoki Otani | Hiroshi Nawashiro | Kimihiro Nagatani | Satoru Takeuchi | Hiroaki Kobayashi | Katsuji Shima
Immunological Manifestations in Paraphenylene Diamine Poisoning

Author(s): Boubaker Charra | Abdelhamid Hachimi | Abdellatif Benslama | Norddine Habti | Brahim Farouqi | Said Motaouakkil
Downregulation of CDKN2A and suppression of cyclin D1 gene expressions in malignant gliomas

Author(s): Liu Weidong | Lv Guohua | Li Yawei | li Lei | Wang Bing
Tyrosine kinases in rheumatoid arthritis

Author(s): Okamoto Hiroshi | Kobayashi Akiko
Long-term follow-up and treatment of congenital alveolar proteinosis

Author(s): Griese Matthias | Ripper Jan | Sibbersen Anke | Lohse Pia | Lohse Peter | Brasch Frank | Schams Andrea | Pamir Asli | Schaub Bianca | Muensterer Oliver | Schön Carola | Glöckner-Pagel Judith | Nicolai Thomas | Reiter Karl | Hector Andreas
Cytotoxicity of VEGF121/rGel on vascular endothelial cells resulting in inhibition of angiogenesis is mediated via VEGFR-2

Author(s): Mohamedali Khalid | Ran Sophia | Gomez-Manzano Candelaria | Ramdas Latha | Xu Jing | Kim Sehoon | Cheung Lawrence | Hittelman Walter | Zhang Wei | Waltenberger Johannes | Thorpe Philip | Rosenblum Michael
Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells

Author(s): Chuang Jiin-Haur | Chuang Hui-Ching | Huang Chao-Cheng | Wu Chia-Ling | Du Yung-Ying | Kung Mei-Lang | Chen Chih-Hao | Chen San-Cher | Tai Ming-Hong
Aberrant upregulation of 14-3-3ơ expression serves as an inferior prognostic biomarker for gastric cancer

Author(s): Zhou Wei-hua | Tang Fang | Xu Jie | Wu Xing | Feng Zhi-ying | Li Hai-gang | Lin Dong-jun | Shao Chun-kui | Liu Quentin
Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain

Author(s): Melemedjian Ohannes | Asiedu Marina | Tillu Dipti | Sanoja Raul | Yan Jin | Lark Arianna | Khoutorsky Arkady | Johnson Jessica | Peebles Katherine | Lepow Talya | Sonenberg Nahum | Dussor Gregory | Price Theodore
An novel role of sphingosine kinase-1 (SPHK1) in the invasion and metastasis of esophageal carcinoma

Author(s): Pan Jian | Tao Yan-Fang | Zhou Zhuan | Cao Bang-rong | Wu Shui-Yan | Zhang Yan-Lan | Hu Shao-Yan | Zhao Wen-Li | Wang Jian | Lou Guo-Liang | Li Zhen | Feng Xing | Ni Jian
Upregulation of microRNA-125b contributes to leukemogenesis and increases drug resistance in pediatric acute promyelocytic leukemia

Author(s): Zhang Hua | Luo Xue-Qun | Feng Dan-Dan | Zhang Xing-Ju | Wu Jun | Zheng Yu-Sheng | Chen Xiao | Xu Ling | Chen Yue-Qin
Characterization of dental pulp stem/stromal cells of Huntington monkey tooth germs

Author(s): Snyder Brooke | Cheng Pei-Hsun | Yang Jinjing | Yang Shang-Hsun | Huang Anderson | Chan Anthony
iCTNet: A Cytoscape plugin to produce and analyze integrative complex traits networks

Author(s): Wang Lili | Khankhanian Pouya | Baranzini Sergio | Mousavi Parvin
The expression and role of protein kinase C (PKC) epsilon in clear cell renal cell carcinoma

Author(s): Huang Bin | Cao Kaiyuan | Li Xiubo | Guo Shengjie | Mao Xiaopeng | Wang Zhu | Zhuang Jintao | Pan Jincheng | Mo Chengqiang | Chen Junxing | Qiu Shaopeng
Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells

Author(s): Kamberov Yana | Kim Jihoon | Mazitschek Ralph | Kuo Winston | Whitman Malcolm
Positron emission tomography in the diagnostic pathway for intracystic infection in adpkd and "cystic" kidneys. a case series

Author(s): Piccoli Giorgina | Arena Vincenzo | Consiglio Valentina | Deagostini Maria | Pelosi Ettore | Douroukas Anastasios | Penna Daniele | Cortese Giancarlo
A mathematical model for targeting chemicals to tissues by exploiting complex degradation

Author(s): Gardiner Bruce | Zhang Lihai | Smith David | Pivonka Peter | Grodzinsky Alan
Design and development of a peptide-based adiponectin receptor agonist for cancer treatment

Author(s): Otvos Laszlo | Haspinger Eva | La Russa Francesca | Maspero Federica | Graziano Patrizia | Kovalszky Ilona | Lovas Sandor | Nama Kaushik | Hoffmann Ralf | Knappe Daniel | Cassone Marco | Wade John | Surmacz Eva
Generation of reactive oxygen species in 1-methyl-4-phenylpyridinium (MPP+) treated dopaminergic neurons occurs as an NADPH oxidase-dependent two-wave cascade

Author(s): Zawada W Michael | Banninger Gregg | Thornton Jennifer | Marriott Beth | Cantu David | Rachubinski Angela | Das Mita | Griffin W Sue | Jones Susan
Nck2 promotes human melanoma cell proliferation, migration and invasion in vitro and primary melanoma-derived tumor growth in vivo

Author(s): Labelle-Côté Mélissa | Dusseault Julie | Ismaïl Salma | Picard-Cloutier Aude | Siegel Peter | Larose Louise
Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice

Author(s): Lin Yi | Yan Haibo | Xiao Yu | Piao Hongmei | Xiang Ruolan | Jiang Lei | Chen Huaxia | Huang Kewu | Guo Zijian | Zhou Wexun | Lu Bao | Gao Jinming
Multiplex serum biomarker assessments: technical and biostatistical issues

Author(s): Butterfield Lisa | Potter Douglas | Kirkwood John
DnaJ homolog Hdj2 Facilitates Japanese Encephalitis Virus Replication

Author(s): Wang Robert | Huang Yu-Ru | Chong Ka-Man | Hung Chun-Yu | Ke Zhi-Long | Chang Ruey-Yi
Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction

Author(s): Giralt Albert | Carretón Olga | Lao-Peregrin Cristina | Martín Eduardo | Alberch Jordi
A novel bacteriophage Tail-Associated Muralytic Enzyme (TAME) from Phage K and its development into a potent antistaphylococcal protein

Author(s): Paul Vivek | Rajagopalan Sanjeev | Sundarrajan Sudarson | George Shilpa | Asrani Jiya | Pillai Renjith | Chikkamadaiah Ravisha | Durgaiah Murali | Sriram Bharathi | Padmanabhan Sriram
Genome wide single cell analysis of chemotherapy resistant metastatic cells in a case of gastroesophageal adenocarcinoma

Author(s): Hjortland Geir | Meza-Zepeda Leonardo | Beiske Klaus | Ree Anne | Tveito Siri | Hoifodt Hanne | Bohler Per | Hole Knut | Myklebost Ola | Fodstad Oystein | Smeland Sigbjorn | Hovig Eivind
Combination of suberoylanilide hydroxamic acid with heavy ion therapy shows promising effects in infantile sarcoma cell lines

Author(s): Oertel Susanne | Thiemann Markus | Richter Karsten | Weber Klaus-J | Huber Peter | Perez Ramon | Brons Stephan | Bischof Marc | Kulozik Andreas | Ehemann Volker | Debus Jürgen | Blattmann Claudia
Ischemic postconditioning attenuates liver warm ischemia-reperfusion injury through Akt-eNOS-NO-HIF pathway

Author(s): Guo Jia | Yang Tong | Sun Xiang | Zhou Ni | Li Fu | Long Dan | Lin Tao | Li Ping | Feng Li
Safety, immunogenicity and preliminary efficacy of multiple-site vaccination with an Epidermal Growth Factor (EGF) based cancer vaccine in advanced non small cell lung cancer (NSCLC) patients

Author(s): Rodriguez Pedro | Neninger Elia | García Beatriz | Popa Xitlally | Viada Carmen | Luaces Patricia | González Gisela | Lage Agustin | Montero Enrique | Crombet Tania
Origin and consequences of brain Toll-like receptor 4 pathway stimulation in an experimental model of depression

Author(s): Gárate Iciar | García-Bueno Borja | Madrigal José | Bravo Lidia | Berrocoso Esther | Caso Javier | Micó Juan | Leza Juan
Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer

Author(s): Hayashi Satoshi | Kumai Takumi | Matsuda Yoshiya | Aoki Naoko | Sato Keisuke | Kimura Shoji | Kitada Masahiro | Tateno Masatoshi | Celis Esteban | Kobayashi Hiroya
Community-associated Staphylococcus aureus infections: pneumonia

Author(s): Marios Karvouniaris | Demosthenes Makris | Epaminondas Zakynthinos
Enhanced Differentiation of Three-Gene-Reprogrammed Induced Pluripotent Stem Cells into Adipocytes via Adenoviral-Mediated PGC-1α Overexpression

Author(s): Pin-I Huang | Yueh-Ching Chou | Yuh-Lih Chang | Yueh Chien | Kuan-Hsuan Chen | Wen-Shin Song | Chi-Hsien Peng | Chin-Hong Chang | Shin-Da Lee | Kai-Hsi Lu | Yi-Jen Chen | Chia-Hua Kuo | Chuan-Chih Hsu | Hsin-Chen Lee | Ming-Chi Yung
Targeted treatment for chronic lymphocytic leukemia

Author(s): Masood A | Sher T | Paulus A | Miller KC | Chitta KS | Chanan-Khan A
Triplex DNA: Importance and its medical application

Author(s): Noori Dalooei M | Mojoodi A
Oral desensitization in children with IgE-mediated cow's milk allergy: a prospective clinical trial

Author(s): Mansouri M | Movahhedi M | Pourpak Z | Akramian R | Shokohi Shormasti R | Mozaffari H | Farhoudi A
T-138C and A-7G polymorphisms in the MGP gene and the association with coronary arthery disease: Iranian patients

Author(s): Abiri M | Sadeghian S | Hakki E | Boroumand MA | Mehdipour P | Izadi M | Keramatipour M
Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies

Author(s): Junko Okabe-Kado | Takashi Kasukabe | Yasuhiko Kaneko
Computer aided screening and evaluation of herbal therapeutics against MRSA infections

Author(s): Sinosh Skariyachan* | Rao Shruti Krishnan | Snehapriya Bangalore Siddapa | Chithra Salian | Prerana Bhora | Denoj Sebastian
Evaluation of JAK2V617F Mutation Prevalence in Myeloproliferative Neoplasm by AS-RT-PCR

Author(s): H Ghafari | P Karimzadeh | B Chahardouli | K Alimoghdam | A Ghavamzadeh | H Dargahi | B Bahar | GH Togeh | F Nadali
gef Gene Expression in MCF-7 Breast Cancer Cells is Associated with a Better Prognosis and Induction of Apoptosis by p53-Mediated Signaling Pathway

Author(s): Houria Boulaiz | Pablo J. Álvarez | Jose Prados | Juan Marchal | Consolación Melguizo | Esmeralda Carrillo | Macarena Peran | Fernando Rodríguez | Alberto Ramírez | Raúl Ortíz | Antonia Aránega
Production, quality control and biodistribiotion studies of 170Tm-DOTA-NHS-Cetuximab

Author(s): Shirvani-Arani Simindokht | Ali Bahrami-Samani | Amir Reza Jalilian | Mohammad Ghannadi-Maragheh
The 14kDa Protein Molecule Isolated from Garlic Suppresses Indoleamine 2, 3-Dioxygenase Metabolites in Mononuclear Cells In vitro

Author(s): Shohreh Nikoo | Mahmood Bozorgmehr | Hasan Namdar Ahmadabad | Mohammad Hassan Zuhair | Seyed Mohammad Moazzeni | Zahra Pourpak | Tooba Ghazanfari
Expression of IP-10 Chemokine is Regulated by Pro-Inflammatory Cytokines in Cultured Hepatocytes

Author(s): Gholamhossein Hassanshahi | Abdollah Jafarzadeh | Zohreh Ghorashi | Nazanin Zia Sheikholeslami | Alan James Dickson
"Flexible Ligand Docking Studies of Matrix Metalloproteinase Inhibitors Using Lamarckian Genetic Algorithm "

Author(s): lOrkideh Ghorban Dadrass | Armin Madadkar Sobhani | Abbas Shafiee | Massoud Mahmoudian
TLR receptors in laryngeal carcinoma – Immunophenotypic, molecular and functional studies

Author(s): Jan Sikora | Magdalena Frydrychowicz | Mariusz Kaczmarek | Bartosz Brzezicha | Iwona Mozer-Lisewska | Miroslaw Szczepañski | Jan Zeromski
Identification of potential apicoplast associated therapeutic targets in human and animal pathogen Toxoplasma gondii ME49

Author(s): Sadegh Saremy | Biplab Bhattacharjee* | Mahdi Eskandarian Boroujeni | Jhinuk Chatterjee | Viditi Mittal
Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer's disease

Author(s): Chia‑Yu Yeh | Bhamini Vadhwana | Alexei Verkhratsky | José J Rodríguez
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