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Search Articles for "lead discovery"

Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum

Author(s): Wang Christian | Mwakalinga Steven | Sutherland Colin | Schwank Samana | Sharp Sarah | Hermsen Cornelus | Sauerwein Robert | Theander Thor | Lavstsen Thomas

Author(s): Akos Toth | Melinda Zomborzsky-Kovács | Gabor Tornyos | Norbert Szalat | Krisztina Kübler
Cell Migration and Invasion Assays as Tools for Drug Discovery

Author(s): Keren I. Hulkower | Renee L. Herber
SERPINE 1 Links Obesity and Diabetes: A Pilot Study

Author(s): Punit Kaur | Michael D. Reis | Glen R. Couchman | Samuel N. Forjuoh | John F. Greene Jr | Alexzander Asea
Novel molecular imaging platform for monitoring oncological kinases

Author(s): Nyati Shyam | Ross Brian | Rehemtulla Alnawaz | Bhojani Mahaveer
Trypanosoma cruzi-Induced Central Nervous System Alterations: From the Entry of Inflammatory Cells to Potential Cognitive and Psychiatric Abnormalities

Author(s): Andréa Alice da Silva | Glaucia Vilar Pereira | Amanda Santos de Souza | Rafael Rodrigues Silva | Mônica Santos Rocha | Joseli Lannes-Vieira
Prolylcarboxypeptidase (PRCP) as a new target for obesity treatment

Author(s): B Shariat-Madar | D Kolte | A Verlangieri | et al
A review of local anesthetic cardiotoxicity and treatment with lipid emulsion

Author(s): Emma Bourne | Christine Wright | Colin Royse
Ocular Proteomics with Emphasis on Two-Dimensional Gel Electrophoresis and Mass Spectrometry

Author(s): Mandal Nakul | Heegaard Steffen | Prause Jan | Honoré Bent | Vorum Henrik

Author(s): Kalyan Kumar.K.V | Swathi Karnati | Mamatha Reddy.B
Pharmacogenomics for Obesity Associated Diabetes: A Review

Author(s): Manoj N. Patil | Virendra G. Kagathara | Uday N. Harle | Timir B. Patel | Roshni P. Solanki | Khushbu R. Chauhan | Rohini R. Pujari
Modeling Natural Anti-Inflammatory Compounds by Molecular Topology

Author(s): María Galvez-Llompart | Riccardo Zanni | Ramón García-Domenech
Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke

Author(s): Kazuhide Hayakawa | Kenichi Mishima | Michihiro Fujiwara
Primed for Discovery: Atomic-Resolution Cryo-EM Structure of a Reovirus Entry Intermediate

Author(s): Shane D. Trask | Kristen M. Guglielmi | John T. Patton
Optimal selection of epitopes for TXP-immunoaffinity mass spectrometry

Author(s): Planatscher Hannes | Supper Jochen | Poetz Oliver | Stoll Dieter | Joos Thomas | Templin Markus | Zell Andreas
Biomarkers for Colorectal Cancer

Author(s): Takuji Tanaka | Mayu Tanaka | Takahiro Tanaka | Rikako Ishigamori
The Clinical Significance of Unknown Sequence Variants in BRCA Genes

Author(s): Valentina Calò | Loredana Bruno | Laura La Paglia | Marco Perez | Naomi Margarese | Francesca Di Gaudio | Antonio Russo
Protein Based Drug Discovery

Author(s): Joshi B. | Gupta G. | Gupta N. | Gupta M. | Trivedi S. | Patil P. | Jhadav A. | Vamsi K.K. | Khairnar Y. | Boraste A. | Mujapara A.
From Editor vol 11, No.4

Author(s): Ugur Demiray
Antiviral Lead Compounds from Marine Sponges

Author(s): Sunil Sagar | Mandeep Kaur | Kenneth P. Minneman
Molecular biology research in neuropsychiatry: India′s contribution

Author(s): Rao T. S. | Ramesh B | Vasudevaraju P | Rao K. S. J.
Some biological aspects of Aristotle's glottology

Author(s): Maricki-Gađanski Ksenija
Peptide Phage Display as a Tool for Drug Discovery: Targeting Membrane Receptors

Author(s): Peter Molek | Borut Strukelj | Tomaz Bratkovic
HPLC Method for the Simultaneous Determination of Ten Annonaceous Acetogenins after Supercritical Fluid CO2 Extraction

Author(s): Haijun Yang | Ning Zhang | Qingqi Zeng | Qiping Yu | Shihuai Ke | Xiang Li
GPCRs Revisited: New Insights Lead to Novel Drugs

Author(s): Richard M. Eglen | Terry Reisine

Author(s): Gupta Praveen kumar | Agrawal Pushpa | Shivakumar Neeta | Hiremath Suhasini.B
Design of New Competitive Dengue Ns2b/Ns3 Protease Inhibitors—A Computational Approach

Author(s): Neni Frimayanti | Chin Fei Chee | Sharifuddin M. Zain | Noorsaadah Abd. Rahman
A Novel Approach for Predicting User Behavior for Improving Web Performance

Author(s): Priyanka Makkar | Payal Gulati | Dr. A.K. Sharma3
An Expressed Sequence Tag collection from the male antennae of the Noctuid moth Spodoptera littoralis: a resource for olfactory and pheromone detection research

Author(s): Legeai Fabrice | Malpel Sébastien | Montagné Nicolas | Monsempes Christelle | Cousserans François | Merlin Christine | François Marie-Christine | Maïbèche-Coisné Martine | Gavory Frédérick | Poulain Julie | Jacquin-Joly Emmanuelle
Ancient DNA from lake sediments: Bridging the gap between paleoecology and genetics

Author(s): Anderson-Carpenter Lynn | McLachlan Jason | Jackson Stephen | Kuch Melanie | Lumibao Candice | Poinar Hendrik
Potent bace-1 inhibitor design using pharmacophore modeling, in silico screening and molecular docking studies

Author(s): John Shalini | Thangapandian Sundarapandian | Sakkiah Sugunadevi | Lee Keun
Immunoreactivity of anti-gelsolin antibodies: implications for biomarker validation

Author(s): Haverland Nicole | Pottiez Gwënaël | Wiederin Jayme | Ciborowski Pawel
Genome-wide SNPs and re-sequencing of growth habit and inflorescence genes in barley: implications for association mapping in germplasm arrays varying in size and structure

Author(s): Cuesta-Marcos Alfonso | Szűcs Péter | Close Timothy | Filichkin Tanya | Muehlbauer Gary | Smith Kevin | Hayes Patrick
Use of cervicovaginal fluid for the identification of biomarkers for pathologies of the female genital tract

Author(s): Zegels Geert | Van Raemdonck Geert | Tjalma Wiebren | Van Ostade Xaveer
On particles in the Arctic stratosphere

Author(s): T. S. Jørgensen
Soft X-ray Laser Microscopy of Lipid Rafts towards GPCR-Based Drug Discovery Using Time-Resolved FRET Spectroscopy

Author(s): Motoyoshi Baba | Tohru Kozasa | Takao Hamakubo | Hiroto Kuroda | Kazuyuki Masuda | Shin Yoneya | Tatsuhiko Kodama
Drug discovery and development for neglected diseases: the DNDi model

Author(s): Eric Chatelain | Jean-Robert Ioset
ESAC Based Channel Aware Routing Using Route Handoff

Author(s): Dr. V.Kavitha, | S.Balaji
Live Cell in Vitro and in Vivo Imaging Applications: Accelerating Drug Discovery

Author(s): Beverley Isherwood | Paul Timpson | Ewan J McGhee | Kurt I Anderson | Marta Canel | Alan Serrels | Valerie G Brunton | Neil O Carragher
Necrotizing enterocolitis: A multifactorial disease with no cure

Author(s): Kareena L Schnabl, John E Van Aerde, Alan BR Thomson, Michael T Clandinin
Efficient algorithms for the discovery of gapped factors

Author(s): Apostolico Alberto | Pizzi Cinzia | Ukkonen Esko
Identification of actinomycetes from plant rhizospheric soils with inhibitory activity against Colletotrichum spp., the causative agent of anthracnose disease

Author(s): Intra Bungonsiri | Mungsuntisuk Isada | Nihira Takuya | Igarashi Yasuhiro | Panbangred Watanalai
Antistaphylococcal and biofilm inhibitory activities of acetyl-11-keto-β-boswellic acid from Boswellia serrata

Author(s): Raja Alsaba | Ali Furqan | Khan Inshad | Shawl Abdul | Arora Daljit | Shah Bhahwal | Taneja Subhash
An Improved Hop-Count Metric for Infrastructural Wireless Mesh Network

Author(s): Paramjeet Kaur Bedi, | Mahendra Singh Aswal, | Praveen Kumar
Harungana madagascariensis in acute and repeated acetaminophen hepatotoxic rats

Author(s): A A Adeneye | J A Olagunju | S O Elias | D O Olatunbosun | A O Mustafa | O I Adeshile | A O Ashaolu | T A Laoye | A O Bamigboye | A O Adeoye
Autophagy in mammalian cells

Author(s): Kadija Abounit | Tiziano M Scarabelli | Roy B McCauley
Otorhinolaryngologic Manifestations of Wegener's Granulomatosis

Author(s): Aleksandra Aleksic | Zorica Novakovic | Dalibor Vranjes | Miroslav Petkovic | Vesna Tomic-Spiric

Author(s): Pandey Gulshan

Author(s): Gajalakshmi S | Vijayalakshmi S | Devi Rajeswari V
Cervical cancer : Promoter hypermethylation and its reversal

Author(s): Abhimanyu Kumar Jha1,2, Mohsen Nikbakht1, Neena Capalash1 q , Jagdeep Kaur1* q
Ionic Channels as Targets for Drug Design: A Review on Computational Methods

Author(s): Gregorio Fernández-Ballester | Asia Fernández-Carvajal | José Manuel González-Ros | Antonio Ferrer-Montiel
Lassa hemorrhagic fever in a late term pregnancy from northern sierra leone with a positive maternal outcome: case report

Author(s): Branco Luis | Boisen Matt | Andersen Kristian | Grove Jessica | Moses Lina | Muncy Ivana | Henderson Lee | Schieffellin John | Robinson James | Bangura James | Grant Donald | Raabe Vanessa | Fonnie Mbalu | Sabeti Pardis | Garry Robert
A Cross-Layer Route Discovery Framework for Mobile Ad Hoc Networks

Author(s): Zhou Bosheng | Marshall Alan | Wu Jieyi | Lee Tsung-Han | Liu Jiakang
Sex in the PAC: A hidden affair in dark septate endophytes?

Author(s): Zaffarano Pascal | Queloz Valentin | Duò Angelo | Grünig Christoph
Antifertility activity evaluation of two derivatives of dihydropyridine compounds on male rats

Author(s): M. Vosooghi | H. Sadeghipour Roodsari | A | Amini | S | Simi
Effect of recycling process on metal ion release from orthodontic brackets at different periods

Author(s): Amini F | Soboti F | Shariati M | Noshad Haghighi Z
In silico prioritization of some quinazolinone for anticonvulsant activity

Author(s): K. S. Lade*, A. G. Nerkar, and S.D.Sawant
Pharmacotherapy of schizophrenia

Author(s): Shahin Akhondzadeh | Khosro Afkham
ITP, Early Presentation of Thymoma

Author(s): Kamran Alimoghaddam | Forough Foroughi | Ali Shahriari Ahmadi | Vahid Farnia | Maryam Tavakkoli | Ardeshir Ghavamzadeh
Sensorial abnormalities: Smell and taste

Author(s): Palheta Neto, Francisco Xavier | Targino, Mauricio Neres | Peixoto, Victor Soares | Alcântara, Flávia Barata | Jesus, Camila Corrêa de | Araújo, Dalila Costa de | Marçal Filho, Eduardo Flávio de Lacerda
Discovery of Popular Structural Properties in a Website for Personalization and Adaptation

Author(s): Haider Ramadhan Al-Lawati | Ahmed Al-Hosni | Abdullah Al-Hamadani | Mohammad Al-Badawi
Guest Editorial

Author(s): Deng-Yiv Chiu | Chen-Shu Wang | Wen-Chih Chang
Holes in Progressively Thinning Arctic Sea Ice Lead to New Ice Algae Habitat

Author(s): Sang Heon Lee | | C. Peter McRoy | Hyoung Min Joo | Rolf Gradinger | Xuehua Cui | Mi Sun Yun | Kyung Ho Chung | Sung-Ho Kang | Chang-Keun Kang | Eun Jung Choy | Seunghyun Son | Eddy Carmack | Terry E. Whitledge
Lobohedleolide induces interleukin-8 production in LPS-stimulated human monocytic cell line THP-1

Author(s): T Oda | WS Wewengkang | M M Kapojos | RE P Mangindaan | J-S Lee | M Namikoshi

Author(s): V.S. Tegeli*, G.B. Gajeli, G.K. Chougule, Y.S. Thorat, U.S. Shivsharan, S.T. Kumbhar,
Extremophiles: A Novel Source of Industrially Important Enzymes

Author(s): Lokendra Kumar | Gyanendra Awasthi | Balvinder Singh
An overview of HCV molecular biology, replication and immune responses

Author(s): Ashfaq Usman | Javed Tariq | Rehman Sidra | Nawaz Zafar | Riazuddin Sheikh
A review of health system infection control measures in developing countries: what can be learned to reduce maternal mortality

Author(s): Hussein Julia | Mavalankar Dileep | Sharma Sheetal | D'Ambruoso Lucia
A novel integrase-containing element may interact with Laem-Singh virus (LSNV) to cause slow growth in giant tiger shrimp

Author(s): Panphut Wattana | Senapin Saengchan | Sriurairatana Siriporn | Withyachumnarnkul Boonsirm | Flegel Timothy
Causal graph-based analysis of genome-wide association data in rheumatoid arthritis

Author(s): Alekseyenko Alexander | Lytkin Nikita | Ai Jizhou | Ding Bo | Padyukov Leonid | Aliferis Constantin | Statnikov Alexander
FIND: A new software tool and development platform for enhanced multicolor flow analysis

Author(s): Dabdoub Shareef | Ray William | Justice Sheryl
Database on pharmacophore analysis of active principles, from medicinal plants

Author(s): Daisy Pitchai | Rajalakshmi Manikkam | Gnanamani Pitchai | Sasikala R. Rajendran
New Generation Novel Drugs Designed For Type 2 Diabetes By Insilico Computational Methods which block IRS4

Author(s): Thanigaivelan 1 | Sampoornam Balakrishnan 2 | Karpagam Veerappan 3 | Rasappan Periannan 4 | Shila Samuel*5
Discovery of new anti-inflammatory drugs from plant origin

Author(s): C.J. Beukelman, E. van den Worm, C. Henriette, Q. van Ufford, B.H. Kroes, A.J.J. van den Berg

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