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Role of erlotinib in first-line and maintenance treatment of advanced non-small-cell lung cancer

Author(s): Noemí Reguart | Andrés Felipe Cardona | Rafael Rosell
Molecular basis and management of gastrointestinal stromal tumors

Author(s): Ulas D Bayraktar, Soley Bayraktar, Caio M Rocha-Lima
Radiolabeled Small Molecule Protein Kinase Inhibitors for Imaging with PET or SPECT

Author(s): Justin W. Hicks | Henry F. VanBrocklin | Alan A. Wilson | Sylvain Houle | Neil Vasdev
Aurora kinase inhibitors: which role in the treatment of chronic myelogenous leukemia patients resistant to imatinib?

Author(s): Giovanni Martinelli | Simona Soverini | Ilaria Iacobucci | Cristina Papayannidis | Daniela Cilloni | Michele Baccarani
New advancements and developments in treatment of renal cell carcinoma: focus on pazopanib

Author(s): C Lance Cowey | Guru Sonpavde | Thomas E Hutson
Erlotinib in the treatment of advanced pancreatic cancer

Author(s): Robin K Kelley | Andrew H Ko
Progress in researches about focal adhesion kinase in gastrointestinal tract

Author(s): Hui Fang Hao, Yoshio Naomoto, Xiao-Hong Bao, Nobuyuki Watanabe, Kazufumi Sakurama, Kazuhiro Noma, Yasuko Tomono, Takuya Fukazawa, Yasuhiro Shirakawa, Tomoki Yamatsuji, Junji Matsuoka, Munenori Takaoka
Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy

Author(s): Sierra J Rafael | Cepero Virna | Giordano Silvia
K-RAS Gene Mutations in Patients with Non-small Cell Lung Cancer

Author(s): Yang ZHANG | Zhenkui PAN | Xing ZHANG | Fei XU | Li ZHANG
Elevated expression of c-kit in small venous malformations of blue rubber bleb nevus syndrome

Author(s): Carolin Mogler | Christian Beck | Andreas Kulozik | Roland Penzel | Peter Schirmacher | Kai Breuhahn
Abscess formation mimicking disease progression, in a patient with metastatic renal cell carcinoma during sunitinib treatment

Author(s): Michalaki Vasiliki | Arkadopoulos Nikolaos | Kondi-Pafiti Agathi | Gennatas Constantine
Tyrosine kinases in etiopathogenesis and therapy of malignant diseases: c-kit activating mutations

Author(s): Stankov Karmen | Bogdanović Gordana | Popović Stevan
Cardiotoxicity of tyrosine kinase inhibitors in chronic myelogenous leukemia therapy

Author(s): Zhenshu Xu | Shundong Cang | Ting Yang | Delong Liu
Molecular Therapies in Thyroid Cancer

Author(s): Timothy Huyck | Mark Agulnik
The dual kinase complex FAK-Src as a promising therapeutic target in cancer

Author(s): Victoria Bolós | Joan Manuel Gasent | Sara López-Tarruella | et al
Anti-angiogenesis therapies: their potential in cancer management

Author(s): Andrew Eichholz | Shairoz Merchant | Andrew M Gaya
Age-related macular degeneration: experimental and emerging treatments

Author(s): Jean Pierre Hubschman | Shantan Reddy | Steven D Schwartz
Comparison of EGFR Mutation Status in Paired Pre- and Post-chemotherapy Serum for Advanced Pulmonary Adenocarcinoma

Author(s): Rubing HAN | Wei ZHONG | Jing ZHAO | Li ZHANG | Ying XIA | Han WANG | Longyun LI | Mengzhao WANG
WT1 PEPTIDE VACCINATION IN COMBINATION WITH IMATINIB THERAPY FOR A PATIENT WITH CML IN THE CHRONIC PHASE

Author(s): Miwako Narita, Masayoshi Masuko, Tohri Kurasaki, Toshiki Kitajima, Shoko Takenouchi, Anri Saitoh, Norihiro Watanabe, Tatsuo Furukawa, Ken Toba, Ichiro Fuse, Yoshifusa Aizawa, Manabu Kawakami, Yoshihiro Oka, Haruo Sugiyama, Masuhiro Takahashi
Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition

Author(s): Corso Simona | Ghiso Elena | Cepero Virna | Sierra J Rafael | Migliore Cristina | Bertotti Andrea | Trusolino Livio | Comoglio Paolo | Giordano Silvia
Nuclear expression of FLT1 and its ligand PGF in FUS-DDIT3 carrying myxoid liposarcomas suggests the existence of an intracrine signaling loop

Author(s): Andersson Mattias | Göransson Melker | Olofsson Anita | Andersson Carola | Åman Pierre
Receptor-Based Virtual Screening of EGFR Kinase Inhibitors from the NCI Diversity Database

Author(s): Kiattawee Choowongkomon | Orathai Sawatdichaikul | Napat Songtawee | Jumras Limtrakul
Systemic treatment of chronic GVHD

Author(s): Michael Schleuning
Gene expression analysis after receptor tyrosine kinase activation reveals new potential melanoma proteins

Author(s): Teutschbein Janka | Haydn Johannes | Samans Birgit | Krause Michael | Eilers Martin | Schartl Manfred | Meierjohann Svenja
EGFR/Met association regulates EGFR TKI resistance in breast cancer

Author(s): Mueller Kelly | Yang Zeng-Quan | Haddad Ramsi | Ethier Stephen | Boerner Julie
Detection of Epidermal Growth Factor Receptor Mutations in Non-small Cell Lung Cancer Tumor Specimens from Various Ways by Denaturing High-performance Liquid Chromatography

Author(s): Siyuan CHEN | Zhihong CHEN | Ailin GUO | Jian SU | Ying HUANG | Shiliang CHEN | Xuchao ZHANG | Xuening YANG | Jinji YANG | Yilong WU
Genome profiling of ERBB2-amplified breast cancers

Author(s): Sircoulomb Fabrice | Bekhouche Ismahane | Finetti Pascal | Adélaïde José | Hamida Azza | Bonansea Julien | Raynaud Stéphane | Innocenti Charlène | Charafe-Jauffret Emmanuelle | Tarpin Carole | Ayed Farhat | Viens Patrice | Jacquemier Jocelyne | Bertucci François | Birnbaum Daniel | Chaffanet Max
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and Casein Kinase II inhibition as a potential treatment option

Author(s): Willems Stefan | Schrage Yvonne | Bruijn Inge | Szuhai Karoly | Hogendoorn Pancras | Bovée Judith
Chromogenic in situ hybridization to detect EGFR gene copy number in cell blocks from fine-needle aspirates of non small cell lung carcinomas and lung metastases from colo-rectal cancer

Author(s): Simone Giovanni | Mangia Anita | Malfettone Andrea | Rubini Vincenza | Siciliano Michele | Di Benedetto Anna | Terrenato Irene | Novelli Flavia | Mottolese Marcella
The future role of personalized medicine in the treatment of glioblastoma multiforme

Author(s): Jing Li | Chunhui Di | Austin K Mattox | et al
Small molecule tyrosine kinase inhibitors in pancreatic cancer

Author(s): Sachin Gupta | Bassel F El-Rayes
Development and targeted use of nilotinib in chronic myeloid leukemia

Author(s): Carmen Fava | Hagop Kantarjian | Jorge Cortes | Elias Jabbour
Sorafenib inhibits tumor growth and vascularization of rhabdomyosarcoma cells by blocking IGF-1R-mediated signaling

Author(s): Wessen Maruwge | Pádraig D’Arcy | Annika Folin | Slavica Brnjic | Johan Wejde | et al
Targeted treatment of chronic myeloid leukemia: role of imatinib

Author(s): Ila Tamascar | Jeyanthi Ramanarayanan
Dasatinib in chronic myeloid leukemia: a review

Author(s): Dolly G Aguilera | Apostolia M Tsimberidou
Nilotinib: optimal therapy for patients with chronic myeloid leukemia and resistance or intolerance to imatinib

Author(s): Ronan Swords | Devalingam Mahalingam | Swaminathan Padmanabhan | Jennifer Carew | Francis Giles
Dasatinib in the treatment of imatinib refractory chronic myeloid leukemia

Author(s): Radhakrishnan Ramchandren | Charles A Schiffer
Multiple roles and therapeutic implications of Akt signaling in cancer

Author(s): Emiliano Calvo | Victoria Bolós | Enrique Grande
HER2 breast cancer therapies: a review

Author(s): Conleth G Murphy | Shanu Modi
Nilotinib for the treatment of chronic myeloid leukemia: An evidence-based review

Author(s): Elias Jabbour | Jorge Cortes | Hagop Kantarjian
BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance

Author(s): Quentmeier Hilmar | Eberth Sonja | Romani Julia | Zaborski Margarete | Drexler Hans
Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer

Author(s): Peraldo-Neia Caterina | Migliardi Giorgia | Mello-Grand Maurizia | Montemurro Filippo | Segir Raffaella | Pignochino Ymera | Cavalloni Giuliana | Torchio Bruno | Mosso Luciano | Chiorino Giovanna | Aglietta Massimo
Circulating endothelial cells are an early predictor in renal cell carcinoma for tumor response to sunitinib

Author(s): Gruenwald Viktor | Beutel Gernot | Schuch-Jantsch Susanne | Reuter Christoph | Ivanyi Philipp | Ganser Arnold | Haubitz Marion
Preclinical evaluation of KIT/PDGFRA and mTOR inhibitors in gastrointestinal stromal tumors using small animal FDG PET

Author(s): Pantaleo Maria | Nicoletti Giordano | Nanni Cristina | Gnocchi Chiara | Landuzzi Lorena | Quarta Carmelo | Boschi Stefano | Nannini Margherita | Di Battista Monica | Castellucci Paolo | Fanti Stefano | Lollini Pier | Bellan Elena | Castelli Mauro | Rubello Domenico | Biasco Guido
Antiproliferative and pro-apoptotic effects afforded by novel Src-kinase inhibitors in human neuroblastoma cells

Author(s): Navarra Michele | Celano Marilena | Maiuolo Jessica | Schenone Silvia | Botta Maurizio | Angelucci Adriano | Bramanti Placido | Russo Diego
Liver cancer: Targeted future options

Author(s): Andreas Pircher | Michael Medinger | Joachim Dr
Tyrosine kinase inhibitors: Multi-targeted or single-targeted?

Author(s): Fleur Broekman | Elisa Giovannetti | Godefridus J Peters
A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers

Author(s): Yasushi Adachi, Hiroyuki Yamamoto, Hirokazu Ohashi, Takao Endo, David P Carbone, Kohzoh Imai, Yasuhisa Shinomura
Critical appraisal of nilotinib in frontline treatment of chronic myeloid leukemia

Author(s): David L DeRemer | Katerina Katsanevas | Celalettin Ustun
Epidermal Growth Factor Receptor in Pancreatic Cancer

Author(s): Melissa Oliveira-Cunha | William G. Newman | Ajith K. Siriwardena
c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1

Author(s): Meryem Güller, Kahina Toualbi-Abed, Agnès Legrand, Laurence Michel, Alain Mauviel, Dominique Bernuau, Fanny Daniel
Three cases of bone metastases in patients with gastrointestinal stromal tumors

Author(s): Valerio Di Scioscio | Laura Greco | Maria Caterina Pallotti | Maria Abbondanza Pantaleo | Alessandra Maleddu | Margherita Nannini | Alberto Bazzocchi | Monica Di Battista | Anna Mandrioli | Cristian Lolli | Maristella Saponara | Giorgio Garzillo | Guido Biasco | Maurizio Zompatori
Tyrosine kinase inhibitors induced immune thrombocytopenia in chronic myeloid leukemia?

Author(s): Avital F. Barak | Lilach Bonstein | Roy Lauterbach | Elizabeth Naparstek | Sigal Tavor
Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor

Author(s): Cristian Lolli | Maria Abbondanza Pantaleo | Margherita Nannini | Maristella Saponara | Maria Caterina Pallotti | Valerio Di Scioscio | Anna Mandrioli | Guido Biasco
EGFR as a therapeutic target in glioblastoma

Author(s): David M Siebert | Sophia F Shakur | Peter Pytel | Lukas Rimas
Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells

Author(s): Dolman MEM | Harmsen S | Pieters EHE | Sparidans RW | Lacombe M | Szokol B | Őrfi L | Kéri G | Storm G | Hennink WE | Kok RJ
Tyrosine kinase domain gene polymorphism of epidermal growth factor receptor in gastric cancer in northern Iran

Author(s): Jeivad F | Abediankenari S | Shokrzadeh M | Ghasemi M | Taghvaei T | Ansari Z | Najafi Fard M | Hassannia H | Sayiari Mazandarani M | Biranvand E
Gastrointestinal stromal tumours: a clinico-pathological study.

Author(s): Hla OO | Pemasari Upali TELISINGHE | Ghazal KAFEEL | Prathibha Parampalli SUBRAHAMANYA | Sowmya Tatti RAJARAM
Tyrosine kinase inhibitors in hematological malignancies

Author(s): Kamila Kosior | Magdalena Lewandowska-Grygiel | Krzysztof Giannopoulos
Study of the role of

Author(s): Marco Tutone | Antonino Lauria | Anna Maria Almerico
Tyrosine kinases in rheumatoid arthritis

Author(s): Okamoto Hiroshi | Kobayashi Akiko
Advances in the treatment of chronic myeloid leukemia

Author(s): Eiring Anna | Khorashad Jamshid | Morley Kimberly | Deininger Michael
Clinical pharmacogenomic testing of KRAS, BRAF and EGFR mutations by high resolution melting analysis and ultra-deep pyrosequencing

Author(s): Borràs Emma | Jurado Ismael | Hernan Imma | Gamundi María | Dias Miguel | Martí Isabel | Mañé Begoña | Arcusa Àngels | Agúndez José | Blanca Miguel | Carballo Miguel
Targeting HSP90 in ovarian cancers with multiple receptor tyrosine kinase coactivation

Author(s): Jiao Yisheng | Ou Wenbin | Meng Fanguo | Zhou Haimeng | Wang Aiyuan
Stromal micropapillary pattern predominant lung adenocarcinoma - a report of two cases

Author(s): Ohe Miki | Yokose Tomoyuki | Sakuma Yuji | Osanai Sachie | Hasegawa Chikako | Washimi Kota | Nawa Kimitoshi | Woo Tetsukan | Hamanaka Rurika | Nakayama Haruhiko | Kameda Yoichi | Yamada Kouzo | Isobe Takeshi
New antiangiogenics in non-small cell lung cancer treatment: Vargatef™ (BIBF 1120) and beyond

Author(s): Gori B | Ricciardi S | Fulvi A | Intagliata S | Del Signore E | de Marinis F
Role of Radiation Therapy in the Management of Renal Cell Cancer

Author(s): Angel I. Blanco | Bin S. Teh | Robert J. Amato
Afatinib treatment in advanced non-small cell lung cancer

Author(s): Hurwitz JL | Scullin P | Campbell L
Structure–Activity Relationship of Halophenols as a New Class of Protein Tyrosine Kinase Inhibitors

Author(s): Xiu E Feng | Wan Yi Zhao | Shu Rong Ban | Cheng Xiao Zhao | Qing Shan Li | Wen Han Lin
Role of EGFR Mutation Status in Patients with Stage III Non-squamous Non-small Cell Lung Cancer Treated with Chemoradiotherapy

Author(s): Fuhai LI | Hua BAI | Xia’nan LI | Meina WU | Rong YU | Anhui SHI | Li YIN | Jie WANG | Guangying ZHU
Advances and challenges in the treatment of breast cancer

Author(s): Guenther J Wiedemann | Sabine Thor-Wiedemann
Metastatic collecting duct carcinoma of the kidney treated with sunitinib

Author(s): Tazi El | Essadi Ismail | Tazi Mohamed | Ahellal Youness | M'rabti Hind | Errihani Hassan
Intrinsic resistance to tyrosine kinase inhibitors is associated with poor clinical outcome in metastatic renal cell carcinoma

Author(s): Busch Jonas | Seidel Christoph | Weikert Steffen | Wolff Ingmar | Kempkensteffen Carsten | Weinkauf Lisa | Hinz Stefan | Magheli Ahmed | Miller Kurt | Grünwald Viktor
Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease

Author(s): Kawase Shigeo | Hattori Noboru | Ishikawa Nobuhisa | Horimasu Yasushi | Fujitaka Kazunori | Furonaka Osamu | Isobe Takeshi | Miyoshi Seigo | Hamada Hironobu | Yamane Takashi | Yokoyama Akihito | Kohno Nobuoki
Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer

Author(s): Serrano Diego | Bleau Anne-Marie | Fernandez-Garcia Ignacio | Fernandez-Marcelo Tamara | Iniesta Pilar | Ortiz-de-Solorzano Carlos | Calvo Alfonso
Non-Hodgkin's lymphoma in a chronic myelocytic leukemia patient treated with imatinib

Author(s): Semra Paydaş | Berna Bozkurt Duman | Melek Ergin
Modified Restriction Enzyme-based Detection of EGFR Mutations in Lung Cancer

Author(s): Fan YANG | Kezhong CHEN | Guanchao JIANG | Jianfeng LI | Jun WANG
Combined 3D-QSAR and Docking Modelling Study on Indolocarbazole Series Compounds as Tie-2 Inhibitors

Author(s): Yuanxin Tian | Jian Xu | Zhonghuang Li | Zhengguang Zhu | Jiajie Zhang | Shuguang Wu
Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP

Author(s): Yuan Yuan | Liao Yu-Min | Hsueh Chung-Tsen | Mirshahidi Hamid
Gastrointestinal Stromal Tumours treated before and after the advent of c-kit immunostaining

Author(s): Sorelli Paolo | Cohen Patrizia | Amo-Takyi Bafour | Theodorou Nikitas | Dawson Peter
The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting

Author(s): Maleddu Alessandra | Pantaleo Maria | Nannini Margherita | Biasco Guido
Improvement of platelet dysfunction in chronic myelogenous leukemia following treatment with imatinib: a case report

Author(s): Shimabukuro-Vornhagen Alexander | Rothe Achim | Nogova Lucia | Kochanek Matthias | Scheid Christoph | von Bergwelt-Baildon Michael
Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension?

Author(s): Hennigs Jan | Keller Gunhild | Baumann Hans | Honecker Friedemann | Kluge Stefan | Bokemeyer Carsten | Brümmendorf Tim | Klose Hans
Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

Author(s): Centeno Irene | Blay Pilar | Santamaría Iñigo | Astudillo Aurora | Pitiot Ana | Osorio Fernando | González-Arriaga Patricia | Iglesias Fernando | Menéndez Primitiva | Tardón Adonina | Freije Jose | Balbín Milagros
Ionizing radiation and inhibition of angiogenesis in a spontaneous mammary carcinoma and in a syngenic heterotopic allograft tumor model: a comparative study

Author(s): Riesterer Oliver | Oehler-Jänne Christoph | Jochum Wolfram | Broggini-Tenzer Angela | Vuong Van | Pruschy Martin
Structure-based drug design and AutoDock study of potential protein tyrosine kinase inhibitors

Author(s): Hamed Ismail Ali | Tomofumi Nagamatsu | Eiichi Akaho
Tumor Resistance to Molecularly Targeted Agents

Author(s): James Chen | Peter S. Edelstein | Philip J. Johnson | Robert Lustig | Lucien Ooi
Psychostimulant Drugs and Neuroplasticity

Author(s): Emilio Fernandez-Espejo | Nieves Rodriguez-Espinosa
Evaluation of monocyte-derived dendritic cells, T regulatory and Th17 cells in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Author(s): Iwona Hus | Jacek Tabarkiewicz | Magdalena Lewandowska | Magdalena Wasiak | Paulina Wdowiak | Maria Kusz | Monika Legieć | Anna Dmoszyńska | Jacek Roliński
Study on Point Mutations of K-ras Gene in Non-small Cell Lung Cancer in Guangxi

Author(s): Weixiang ZHONG | Mingwu CHEN | Lei XIAN | Manhong LI
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