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9. Stem cells: A window to regenerative dentistry

Author(s): Mallika Sethi | Amit Dua | Vidya Dodwad

Journal: International Journal of Pharmaceutical and Biomedical Research (IJPBR)
ISSN 0976-0350

Volume: 03;
Issue: 03;
Start page: 175;
Date: 2012;
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Keywords: Periodontitis | Periodontal regeneration | Stem cells

Periodontitis is an inflammatory disease which manifests clinically as loss of supporting periodontal tissues including periodontal ligament and alveolar bone. For decades periodontists have sought ways to repair the damage which occurs during periodontitis. This has included the use of a range of surgical procedures, the use of a variety of grafting materials and growth factors, and the use of barrier membranes. To date periodontal regeneration is considered to be biologically possible but clinically unpredictable. Recently, reports have begun to emerge demonstrating that populations of adult stem cells reside in the periodontal ligament of humans and other animals. Stem cell biology, an emerging field of research, provides promising methods in vitro as well as in vivo in animal models which make speculation about a future application in human dentistry reasonable. This opens the way for new cell-based therapies for periodontal regeneration. This review provides brief insights about stem cell basics, the state of art in human dental stem cell research and their potential role in periodontal regeneration.
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