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Active Continuous-Flow Micromixer Using an External Braille Pin Actuator Array

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Author(s): Yawar Abbas | Junichi Miwa | Roland Zengerle | Felix von Stetten

Journal: Micromachines
ISSN 2072-666X

Volume: 4;
Issue: 1;
Start page: 80;
Date: 2013;
Original page

Keywords: active micromixer | continuous-flow | chaotic advection | channel wall deflection | PDMS chip | cell sample dilution | microfluidic Braille pin actuated platform

ABSTRACT
We present a continuous-flow active micromixer based on channel-wall deflection in a polydimethylsiloxane (PDMS) chip for volume flows in the range up to 2 μL s−1 which is intended as a novel unit operation for the microfluidic Braille pin actuated platform. The chip design comprises a main microchannel connected to a series of side channels with dead ends aligned on the Braille pins. Computer-controlled deflection of the side-channel walls induces chaotic advection in the main-channel, which substantially accelerates mixing in low-Reynolds number flow. Sufficient mixing (mixing index MI below 0.1) of volume flows up to 0.5 μL s−1 could be achieved within residence times ~500 ms in the micromixer. As an application, continuous dilution of a yeast cell sample by a ratio down to 1:10 was successfully demonstrated. The mixer is intended to serve as a component of bio-analytical devices or as a unit operation in the microfluidic Braille pin actuated platform.
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