Academic Journals Database
Disseminating quality controlled scientific knowledge

ADAM-15 Disintegrin-Like Domain Structure and Function

ADD TO MY LIST
 
Author(s): Dong Lu | Mike Scully | Vijay Kakkar | Xinjie Lu

Journal: Toxins
ISSN 2072-6651

Volume: 2;
Issue: 10;
Start page: 2411;
Date: 2010;
Original page

Keywords: ADAM protein | Snake venom toxin | disintegrin | integrin | RGD-motif

ABSTRACT
The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals. Human ADAM-15 is the only member of the ADAM family with the integrin binding motif Arg-Gly-Asp (RGD) in its disintegrin-like domain. This motif is also found in most snake venom disintegrins and other disintegrin-like proteins. This unique RGD motif within ADAM-15 serves as an integrin ligand binding site, through which it plays a pivotal role in interacting with integrin receptors, a large family of heterodimeric transmembrane glycoproteins. This manuscript will present a review of the RGD-containing disintegrin-like domain structures and the structural features responsible for their activity as antagonists of integrin function in relation to the canonical RGD template.
RPA Switzerland

Robotic Process Automation Switzerland

    

Tango Jona
Tangokurs Rapperswil-Jona