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Alteration of the Lipid Peroxidation Values and Endothelium State in Pregnant Females with a Ferrodeficient Anemia at the Background of Treatment with a Ferrum (III) Hydroxide Polymaltosate Preparation

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Author(s): V.B. Kuzin | L.V. Lovtsova | A.L. Barsuk | A.A. Ganenkov | I.E. Okruth

Journal: Sovremennye Tehnologii v Medicine
ISSN 2076-4243

Issue: 4;
Start page: 51;
Date: 2010;
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Keywords: Ferrodeficient anemia | Ferrum preparations | Lipid peroxidation | Endothelium state

ABSTRACT
Aim of investigation is a study of the lipid peroxidation values and endothelium state in pregnant females with a ferrodeficient anemia at the background of treatment with a ferrum (III) hydroxide polymaltosate preparation.Materials and methods. 66 pregnant females, including 35 ones with a ferrodeficient anemia and 31 — without the clinical and laboratory signs of a ferrum deficiency, are included into investigation. The pregnant females of the 1st group have been receiving a ferrum (III) hydroxide polymaltosate preparation (ferrum medicinal) by a tablet twice a day during 30 days. The pregnant females of a control group were observed by the obstetrician-gynecologist. The lipid peroxidation values (the dienic and trienic conjugate, Schiff’s base content) were investigated with a spectrophotometry method, the antioxidant system activity — with a method of induced biochemiliminescence. The endothelium state values (the endothelin level (1—21) and the Willebrand’s factor activity) were detected with a method of immunoenzymatic analysis, a content of the nitrogen oxide stable metabolites was assessed with a use of a spectrophotometric method.Results. The higher initial levels of all the studied lipoperoxidation products as well as the antioxidant system activity, the nitrogen oxide content and the Willebrand’s factor activity are marked in a blood serum of pregnant females with a ferrodeficient anemia compared to pregnant females without the ferrum deficiency signs. An increase of the dienic conjugate content and the antioxidant system activity in a blood serum of pregnant females with a ferrodeficient anemia is observed in 30 days of the ferrum studied preparation use. Besides, a substantial alteration of the endothelium state values is not revealed.Conclusion. A dynamic control of the lipid peroxidation values and endothelium state, especially in patients with attendant diseases, accompanied by the endothelium dysfunction, is recommended considering a necessity of the ferrum preparation durative use for a ferrodeficient anemia treatment.
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