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Altered blood sphingolipidomics and elevated plasma inflammatory cytokines in combat veterans with post-traumatic stress disorder

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Author(s): Samar M. Hammad | Jean-Philip Truman | Mohammed M. Al Gadban | Kent J. Smith | Waleed O. Twal | Mark B. Hamner

Journal: Neurobiology of Lipids
ISSN 1683-5506

Volume: 10;
Start page: 2;
Date: 2011;
Original page

Keywords: PTSD | post-traumatic stress disorder | sphingolipidomics | HPLC-MS/MS | sphingolipids | sphingomyelinase | sphingosine 1-phosphate | ceramide | cytokine | interleukin | IL-6 | IL-10 | TNF | tumor necrosis factor | interferon | HDL | LDL | cholesterol | hyperlipidemia | statins

ABSTRACT
Patients with post-traumatic stress disorder (PTSD) have greater risk of developing cardiovascular disease (CVD). While chronically elevated plasma cholesterol and pro-inflammatory cytokines levels increase CVD risk, several studies have shown that cholesterol reduction does not reduce CVD risk. Acid sphingomyelinase (ASMase) activation has been implicated in both CVD and major depressive disorder. We investigated plasma pro-inflammatory cytokine levels, ASMase activity, and changes in sphingolipids in PTSD patients compared to healthy controls. Levels of interleukin 6, interleukin 10, interferon-γ and tumor necrosis factor-α were higher in PTSD patients than controls. Plasma ASMase activity and sphingosine 1-phosphate were higher in the PTSD group (1.6-fold and 2-fold, respectively; p
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