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An alternative synthesis of (+) - propranolol and (+) – atenolol

Author(s): Aphiwat Teerawutgulrag

Journal: Maejo International Journal of Science and Technology
ISSN 1905-7873

Volume: 6;
Issue: 03;
Start page: 372;
Date: 2012;
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Keywords: beta-blockers | propranolol | atenolol

Herein, a simple synthesis pathway of beta-blockers starting from allyl amine ispresented. This synthesis features the opening of an epoxide ring with phenol derivatives followed by N-alkylation with iso-propylbromide to produce racemic propranolol and atenolol.
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