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An analysis of factors contributing to poor outcomes in Cystic Fibrosis

Author(s): Kirsten Murray

Journal: Scottish Universities Medical Journal
ISSN 2049-8454

Volume: 1;
Issue: 1;
Start page: 23;
Date: 2012;
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Keywords: cystic fibrosis | outcomes

Cystic fibrosis [CF] is one of the most frequently seen inherited conditions in Europeans and it affects 1 in 2381 births in the UK1,2. It is an autosomal recessive condition resulting from a mutation in the CFTR (cystic fibrosis transmembrane conductance regulator) gene on chromosome 73. This affects the movement of chloride ions, leading to a disruption of sodium and water movement therefore secretions produced are abnormally thick. These thick secretions cause inflammation and affect the functioning of organs by damaging their cells. This article will review the factors and varaible known to worsen outcomes in CF patients.
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